Table 3 Time kill curve against β-lactamase negative H. influenzae strains (N = 200)
Antibiotic | Â | Mean changes in colony counts vs initial inocula after | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | 3 h | 6 h | 12 h | 24 h | ||||
| Â | Â | CO2 | Air | CO2 | Air | CO2 | Air | CO2 | Air |
Telithromycin | 4 × MIC | -1.42 | -1.72 | - 2.81 | -2.61 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.64 | -0.18 | -1.87 | -1.91 | -2.71 | -2.45 | > -3.0 | > -3.0 |
|  | 1 × MIC | -0.36 | -0.15 | -0.99 | -0.26 | -1.21 | -1.18 | -1.32 | -1.81 |
|  | 1/2 × MIC | 0.22 | 0.39 | 1.20 | 0.85 | 2.27 | 2.43 | 3.74 | 4.12 |
|  | 1/4 × MIC | 0.43 | 0.35 | 1.51 | 1.35 | 2.94 | 2.54 | 4.93 | 4.59 |
| Â | ELF | -1.43 | -1.54 | -2.43 | > -3.0 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
Clarithromycin | 4 × MIC | -1.03 | -0.94 | -2.18 | -2.32 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.75 | -0.69 | -1.80 | -1.61 | -2.42 | -2.30 | > -3.0 | > -3.0 |
|  | 1 × MIC | -0.23 | -0.49 | -0.75 | 0.66 | -0.91 | -1.04 | -1.18 | -1.58 |
|  | 1/2 × MIC | -0.19 | -0.19 | 0.69 | 0.66 | 1.57 | 2.71 | 3.81 | 4.31 |
|  | 1/4 × MIC | 0.51 | 0.45 | 1.69 | 1.40 | 2.93 | 2.99 | 5.01 | 4.84 |
| Â | ELF | -1.09 | -1.26 | -2.68 | > -3.0 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
Azithromycin | 4 × MIC | -1.99 | -1.38 | -2.86 | -2.44 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.98 | -0.94 | -1.73 | -1.88 | > -3.0 | -2.57 | > -3.0 | > -3.0 |
|  | 1 × MIC | -0.10 | -0.06 | -0.56 | -0.45 | -1.55 | -1.84 | -1.80 | -1.99 |
|  | 1/2 × MIC | 0.18 | 0.29 | 0.91 | 1.03 | 1.71 | 2.31 | 3.49 | 3.41 |
|  | 1/4 × MIC | 0.39 | 0.36 | 1.38 | 1.63 | 2.23 | 2.53 | 4.58 | 4.28 |
| Â | ELF | -0.45 | -1.22 | -2.40 | -2.12 | -2.72 | -2.55 | > -3.0 | > -3.0 |
Control | Â | 0.64 | 0.38 | 1.96 | 1.95 | 4.32 | 3.05 | 5.44 | 4.90 |