Skip to main content

Advertisement

Table 3 Time kill curve against β-lactamase negative H. influenzae strains (N = 200)

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Antibiotic   Mean changes in colony counts vs initial inocula after
   3 h 6 h 12 h 24 h
   CO2 Air CO2 Air CO2 Air CO2 Air
Telithromycin 4 × MIC -1.42 -1.72 - 2.81 -2.61 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.64 -0.18 -1.87 -1.91 -2.71 -2.45 > -3.0 > -3.0
  1 × MIC -0.36 -0.15 -0.99 -0.26 -1.21 -1.18 -1.32 -1.81
  1/2 × MIC 0.22 0.39 1.20 0.85 2.27 2.43 3.74 4.12
  1/4 × MIC 0.43 0.35 1.51 1.35 2.94 2.54 4.93 4.59
  ELF -1.43 -1.54 -2.43 > -3.0 > -3.0 > -3.0 > -3.0 > -3.0
Clarithromycin 4 × MIC -1.03 -0.94 -2.18 -2.32 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.75 -0.69 -1.80 -1.61 -2.42 -2.30 > -3.0 > -3.0
  1 × MIC -0.23 -0.49 -0.75 0.66 -0.91 -1.04 -1.18 -1.58
  1/2 × MIC -0.19 -0.19 0.69 0.66 1.57 2.71 3.81 4.31
  1/4 × MIC 0.51 0.45 1.69 1.40 2.93 2.99 5.01 4.84
  ELF -1.09 -1.26 -2.68 > -3.0 > -3.0 > -3.0 > -3.0 > -3.0
Azithromycin 4 × MIC -1.99 -1.38 -2.86 -2.44 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.98 -0.94 -1.73 -1.88 > -3.0 -2.57 > -3.0 > -3.0
  1 × MIC -0.10 -0.06 -0.56 -0.45 -1.55 -1.84 -1.80 -1.99
  1/2 × MIC 0.18 0.29 0.91 1.03 1.71 2.31 3.49 3.41
  1/4 × MIC 0.39 0.36 1.38 1.63 2.23 2.53 4.58 4.28
  ELF -0.45 -1.22 -2.40 -2.12 -2.72 -2.55 > -3.0 > -3.0
Control   0.64 0.38 1.96 1.95 4.32 3.05 5.44 4.90