F. tularensis subsp. novicida and K. pneumoniae are found in blood of infected mice at early time points. In order to determine the presence of F. tularensis subsp. novicida as well as K. pneumoniae in blood at early time points mice were infected with 2 × 104 CFU/20 μl and 2 × 109 CFU/20 μl. Data correspond to the average of 4 mice per infectious agent and dose and are given as Log CFU/200 μl. Mice were sacrificed 2 hrs, 6 hrs and 24 hrs pi, blood was plated and CFU were counted. The data obtained from mice infected with F. tularensis subsp. novicida at each time point and each bacterial dose was compared statistically by using a two tail Student's t-test to the data obtained from mice infected with K. pneumoniae. * = p < 0.05, ** = p < 0.01 and *** = p < 0.005.