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Table 1 Significantly regulated genes of the VraSR-dependent cell wall stress response [12] in this study1

From: The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus

N315 ORF

Gene

Gene product

Product function

Fold change2

    

SA137/93A

SA137/93G

SG511

    

(0.5 × MIC)

(0.5 × MIC)

(0.15 × MIC)

(1 × MIC)

SA0531

proP

proline/betaine transporter homologue

Protein transport and binding

2.4

2.7

 

0.6

SA0536

 

hypothetical protein

 

30.2

17.1

8.5

26.6

SA0608

 

hypothetical protein

 

2.7

3.8

 

9.2

SA0825

spsA

type-I signal peptidase

Protein secretion

2.2

1.4

 

3.9

SA0909

fmtA

FmtA, autolysis and methicillin resistance-related protein

Pathogenic factors

9.3

3.8

6.3

6.3

SA0914

 

hypothetical protein, similar to chitinase B

 

14.2

3.9

 

15.3

SA0931

 

hypothetical protein

 

4.9

3.2

 

6.2

SA1183

opuD

glycine betaine transporter

Protein transport and binding

0.9

0.5

 

0.5

SA1255

 

PTS system, glucose-specific enzyme IIA component

Protein transport and binding

4.7

10.7

2.6

13.1

SA1282

recU

recombination protein U homologue

DNA recombination

3.6

2.5

2.2

2.5

SA1283

pbp2

penicillin-binding protein 2

Cell wall related genes

3.4

2.3

2.7

3.5

SA1476

 

hypothetical protein

 

11.5

11.3

6.5

15.9

SA1548

 

hypothetical protein, similar to acylglycerol- 3-phosphate-O-acyltransferase homologue

Metabolism of lipids

0.7

0.5

 

0.6

SA1549

 

heat-shock protein homologue, similar to serine proteinase

Adaptation to atypical conditions

7.1

4.6

3.9

5.6

SA1657

 

conserved hypothetical protein

 

1.3

2.3

 

0.9

SA1659

prsA

peptidyl-prolyl cis/trans isomerase homologue

Protein folding

10.8

18.1

10.0

33.3

SA1691

sgtB

hypothetical protein, similar to penicillin-binding protein 1A/1B

Cell wall related genes

13.1

8.8

4.8

9.7

SA1700

vraR

two-component response regulator

RNA synthesis – Regulation

13.3

8.0

7.3

17.3

SA1701

vraS

two-component sensor histidine kinase

Sensors (signal transduction)

11.7

8.9

5.8

17.0

SA1702

 

conserved hypothetical protein

 

10.4

9.4

4.4

12.2

SA1703

 

hypothetical protein

 

31.6

24.8

6.8

45.4

SA1711

 

hypothetical protein, similar to DNA-damage inducible protein P

DNA replication, modification, repair

2.2

1.6

 

3.4

SA1712

 

conserved hypothetical protein

 

24.7

21.0

5.0

29.4

SA1926

murZ

UDP-N-acetylglucosamine 1- carboxylvinyl transferase 2

Cell wall related genes

3.2

4.4

3.9

6.1

SA2103

 

hypothetical protein, similar to lyt divergon expression attenuator LytR

RNA synthesis – Regulation

6.4

6.1

4.4

8.0

SA2113

 

hypothetical protein

 

14.9

11.8

4.9

11.4

SA2146

tcaA

TcaA protein

 

3.3

1.6

2.2

4.0

SA2220

 

conserved hypothetical protein

 

7.0

12.2

3.7

21.4

SA2221

 

hypothetical protein

 

25.6

18.3

5.2

42.7

SA2222

 

hypothetical protein, similar to TcaB

Protein transport and binding

1.2

0.6

 

1.0

SA2296

 

hypothetical protein, similar to transcriptional regulator MerR

RNA synthesis – Regulation

8.1

10.4

3.9

5.5

SA2297

 

hypothetical protein, similar to GTP-pyrophosphokinase

Nucleotide, nucleic acid metabolism

9.1

14.1

3.9

10.3

SA2298

 

conserved hypothetical protein

 

1.8

2.2

 

1.9

SA2413

 

sulfite reductase flavoprotein (NADPH)

Metabolism of sulfur

1.7

2.2

 

2.3

SA2480

drp35

drug responsive protein 35

 

2.7

3.4

2.8

2.8

  1. 1 Significant changes of gene expression were determined by implementing SAM (significance analysis of microarrays; http://www-stat.stanford.edu/~tibs/SAM/) [37].
  2. 2 Fold change in transcript level indicated as mean of the "median of ratios" compared to control cells. Fold change in bold = classified as "significantly" regulated in this strain by SAM.
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BMC Microbiology

ISSN: 1471-2180

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