Skip to main content

Table 1 Survival analysis of A/Jcr mice treated with mAb prior to i.v. infection with B. anthracis Sterne strain 34F2

From: Passive administration of monoclonal antibodies to Anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis

Exp.

Group Condition

mAb Dose (mg/mouse)

n

Mean survival (Days)

Median Survival (Days)

Survive1

P value2

I

PBS

 

8

4.13

4

0

 
 

64F8 (IgG1)

0.25

8

5.75

4

1

.14

 

64F8

0.5

8

4.88

4

0

.10

 

64F8

1.0

8

7.25

5

2

.02

 

80C9 (IgM)

0.25

8

8.25

4

3

.05

 

80C9

0.5

8

5.88

4

1

.09

 

80C9

1.0

8

4.50

4

0

.20

 

64F8 + 80C9

0.5 + 0.5

4

8.0

6

1

0.002

II

PBS

 

10

5.40

5

0

 
 

53C2 (IgM)

0.1

10

8.40

6

1

0.02

III

PBS

 

10

3.90

4

0

 
 

64F8 + 16G2 (IgG1+IgG2b)

0.1 + 0.1

10

4.60

4

0

0.023

 

64F8 + 53C2 (IgG1+gM)

0.1 + 0.1

10

4.20

4

1

0.44

 

64F8 + 80C9 (IgG1+IgM)

0.1 + 0.1

10

4.70

4

0

0.09

IV

PBS

 

10

5.20

5

0

 
 

64F8 (IgM)

0.1

10

6.90

6

1

0.06

 

80C9 (IgM)

0.1

10

8.10

6

2

0.03

 

64F8 + 80C9

0.1 + 0.1

10

7.30

7

1

0.01

  1. 1Number of long-term survivors
  2. 2 P value relative to PBS by log rank analysis