Homology of predicted new chromosomally-encoded Qnr proteins. The Figure shows the alignment of chromosomally-encoded putative Qnr proteins from the analysis of around 1000 genomes and metagenomes. The figure includes one member of each plasmidic Qnr protein family (highlighted in red), so that the similarities are clearer. The putative Qnr protein from the sea metagenome is also included (MtgQnr). As shown in the Figure, conservation is high along the proteins, although the similarities are lower at their N-terminus. The automated annotation of Swoqnr presents two stop codons. Since we ignore whether this is a sequence mistake or Swoqnr is a pseudogene, a manual translation of its nucleotide sequence was performed for this alignment. Stop codons are represented with an X. Accession numbers of the proteins used for the alignment are: AhQnr (YP_854820.1), AsQnr (YP_001143795.1), MsQnr (ZP_01897167.1), QnrA1 (ACA43024), QnrB1 (ABG82188), QnrS1 (ABU86826), SbeQnr (ZP_02157732.1), SfrQnr (YP_750786.1), SliQnr (ABO22341.1), SmQnr (ZP_01643096.1), SpaQnr (ABV89003.1), SprQnr (YP_001478290.1), SseQnr (ABV35251.1), SwoQnr (ZP_01539189.1), PpQnr (CAG21998.1), PsQnr (EAS39797.1), ValQnr (ZP_01261394.1), VanQnr (ZP_01234687.1), VfQnr (ZP_02136549.1), VhQnr (ZP_01985396.1), VpQnr (ZP_01990287.1), VshQnr (ZP_01866232.1), VspQnr (ZP_00989608.1), VvQnr (AAO07889.1) and MtgQnr (AACY020347520).