Organization of the genes involved in acetone metabolism in H. pylori and H. acinonychus strains. Gene designations are indicated below each arrow (not drawn to scale). Open reading frames that were not given a gene designation in the annotated genome sequences are indicated with either an hp designation (for H. pylori 26695), a jhp designation (for H. pylori J99), or only the open reading frame number (for H. pylori HPAG1 and A. acinonychis strain Sheeba). Orthologous genes in the four strains are the same color. The genes jhp0628 in H. pylori J99 and 0671 in H. pylori HPAG1 correspond to a fusion of hp0688 and hp0689 from H. pylori 26695. H. pylori J99 and HPAG1 have two genes within this region, jhp0629 (HPAG1_0672) and jhp0630 (HPAG1_0672), that encode a type II DNA methyltransferase and a type II restriction enzyme, respectively, and are not found in H. pylori 26695. Functions of the products of the genes within the acetone metabolism cluster are described in the text. The proposed functions of the products of the surrounding genes are: fecA, iron(III) dicitrate transport protein; feoB, iron(II) transport protein; dgkA, diacylglycerol kinase; gyrA, subunit A of DNA gyrase; dcuA, anaerobic C4-dicarboxylate transporter; and ansB, asparaginase II.