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Table 2 In vitro antifungal susceptibility of all oral yeast isolates (n = 296)

From: Species distribution and in vitro antifungal susceptibility of oral yeast isolates from Tanzanian HIV-infected patients with primary and recurrent oropharyngeal candidiasis

Species/Antifungal agent MIC (μ/ml) %R*
  MIC Range MIC50 MIC90 GM  
C. albicans (250)      
Amphotericin B 0.125 – 1 0.5 0.5 0.326  
Nystatin 2 – >16 4 4 3.377  
Fluconazole 0.063 – 32 0.25 2 0.330 0
Itraconazole 0.016 – >16 0.016 0.063 0.021 4
Miconazole 0.016 – 4 0.016 0.063 0.025  
Clotrimazole 0.125 – 2 1 2 0.474  
C. glabrata (20)      
Amphotericin B 0.5 – 1 0.5 1 0.545  
Nystatin 2 – 4 4 4 3.668  
Fluconazole 2 – 64 16 32 13.22 5
Itraconazole 0.016 – 4 1 4 0.615 55
Miconazole 0.063 – 0.5 0.25 0.5 0.189  
Clotrimazole 0.125 – 2 1 2 0.474  
C. krusei (10)      
Amphotericin B 0.5 – 1 1 1 0.683  
Nystatin 2 – 8 4 4 0.965  
Fluconazole 64 – >64 64 >64 76.1 100
Itraconazole 0.031 – 0.5 0.125 0.5 0.134 0
Miconazole 1 – 2 2 2 1.464  
Clotrimazole 0.063 – 0.25 0.125 0.125 0.116  
C. tropicalis (8)      
Amphotericin B 0.25 – 1 0.5 - 0.458  
Nystatin 2 – 4 4 - 3.084  
Fluconazole 1 – >64 16 - 14.67 50
Itraconazole 0.016 – 2 0.5 - 0.176 37.5
Miconazole 0.125 – 4 2 - 0.840  
Clotrimazole 0.031 – 4 2 - 0.337  
C. kefyr (3)      
Amphotericin B 0.5 – 0.5 0.5 - 0.5  
Nystatin 2 – 4 2 - 2.244  
Fluconazole 0.25 – 0.5 0.5 - 0.396 0
Itraconazole 0.016 – 0.031 0.031 - 0.019 0
Miconazole 0.016 – 0.016 0.016 - 0.016  
Clotrimazole 0.016 – 0.016 0.016 - 0.016  
C. pintolopesii (1)      
Amphotericin B 0.5 - - -  
Nystatin 4 - - -  
Fluconazole 16 - - - 0
Itraconazole 1 - - - 100
Miconazole 0.25 - - - -
Clotrimazole 1 - - - -
C. dubliniensis (1)      
Amphotericin B 0.25 - - -  
Nystatin 4 - - -  
Fluconazole 0.5 - - - 0
Itraconazole 0.016 - - - 0
Miconazole 0.016 - - -  
Clotrimazole 0.016 - - -  
S. cerevisiae (3)      
Amphotericin B 0.5 – 1 0.5 - 0.445  
Nystatin 2 – 4 4 - 2.828  
Fluconazole 8 – 8 8 - 8 0
Itraconazole 0.25 – 0.5 0.25 - 0.353 0
Miconazole 0.063 – 0.25 0.063 - 0.088  
Clotrimazole 0.063 – 1 0.063 - 0.099  
All isolates (296)      
Amphotericin B 0.125 – 1 0.5 0.5 0.352  
Nystatin 2 – >16 4 4 3.39  
Fluconazole 0.063 – >64 0.5 16 0.592 5
Itraconazole 0.016 – >16 0.016 0.5 0.031 8.4
Miconazole 0.016 – 4 0.031 1 0.036  
Clotrimazole 0.016 – 4 0.016 1 0.029  
  1. MIC50 – MIC value able to inhibit 50% of the isolates tested.
  2. MIC90 – MIC value able to inhibit 90% of the sample tested.
  3. GM – Geometric Mean.
  4. R* – Percent resistance using interpretive breakpoint criteria of the CLSI (2002): Itraconazole resistance ≥ 1; Fluconazole resistance ≥ 64 μg/ml.