Figure 4
From: Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant
Genealogy of BCG vaccine substrains. Genealogy of BCG vaccine substrains, modified from [6] with permission, copyright (2007) National Academy of Sciences, U.S.A., displaying the original virulent ancestor strain Mycobacterium bovis (isolated by Nocard in 1908) and the subsequent series of genomic alteration including deletions of regions of difference (RD), single nucleotide polymorphisms, and duplications of genomic regions. The recA alteration (recA_D140*), the mmaA3 point mutation [8], and the 22-bp deletion in Rv3405c in BCG Japan [39] have been added to the scheme.