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Table 1 A position specific scoring matrix for identification of potential Kex2 substrate proteins.

From: Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris

  P4 P3 P2 P1
A 0.25 0.64 0 0
C 0.05 0.71 0 0
D 0.05 0.27 0 0
E 0.05 0.62 0 0
F 0.60 0.99 0 0
G 0.05 0.70 0 0
H 0.73 1.00 0 0
I 0.28 0.55 0 0
K 0.72 0.60 0.50 0
L 0.09 0.90 0 0
M 0.53 0.71 0 0
N 0.49 0.69 0 0
P 0.20 0.01 0 0
Q 0.41 0.71 0 0
R 1.00 0.60 0.50 1.0
S 0.17 0.64 0 0
T 0.17 0.77 0 0
V 0.56 0.91 0 0
W 0.32 0.88 0 0
Y 0.47 0.85 0 0
  1. The matrix represents the affinity of Kex2 towards the respective amino acid residues of positions P4-P1 relative to the cleavage site. Scores were calculated from biochemical and mating efficiency data given in the literature, as outlined in the text.