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Table 1 A position specific scoring matrix for identification of potential Kex2 substrate proteins.

From: Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris

 

P4

P3

P2

P1

A

0.25

0.64

0

0

C

0.05

0.71

0

0

D

0.05

0.27

0

0

E

0.05

0.62

0

0

F

0.60

0.99

0

0

G

0.05

0.70

0

0

H

0.73

1.00

0

0

I

0.28

0.55

0

0

K

0.72

0.60

0.50

0

L

0.09

0.90

0

0

M

0.53

0.71

0

0

N

0.49

0.69

0

0

P

0.20

0.01

0

0

Q

0.41

0.71

0

0

R

1.00

0.60

0.50

1.0

S

0.17

0.64

0

0

T

0.17

0.77

0

0

V

0.56

0.91

0

0

W

0.32

0.88

0

0

Y

0.47

0.85

0

0

  1. The matrix represents the affinity of Kex2 towards the respective amino acid residues of positions P4-P1 relative to the cleavage site. Scores were calculated from biochemical and mating efficiency data given in the literature, as outlined in the text.