Figure 7

Sequence Alignment of fungal Kex2-like proteins. A protein sequence alignment of the residues involved in substrate specificity determination shows that the electrostatic properties of the binding regions are highly conserved. Red: positive charges, blue: negative charges, orange: polar residues, green: apolar residues, : Propeptide cleavage site, numbering "a" through "E" refers to residues used in Table 2, which lists the respective binding pockets and references.