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Figure 3 | BMC Microbiology

Figure 3

From: Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies

Figure 3

Anti-rotavirus HBC combination treatment with different species of Lactobacilli. Mice were fed lactobacilli daily, either alone or supplemented with 10 μg anti-rotavirus HBC and challenged with RRV on day 0. Diarrhea prevalence was recorded every day and is presented as percentage prevalence. Test of significance was performed using Fischer's exact test. (A) L. paracasei [15], in combination with HBC, was able to achieve a 58% better protection than that imparted by bacteria alone on day 2. On day 3 the combination treatment achieved statistically significant reduction in diarrhea prevalence in comparison to infected but untreated mice (p = 0.001) and 53% better protection than L. paracasei [15] alone. (B) L. rhamnosus GG alone caused a significant reduction in diarrhea prevalence in comparison to untreated mice on day 3 (p = 0.009) and in combination with HBC this effect was further enhanced (p = 0.003). (C) On day 3, protection conferred by combined therapy of L. reuteri strain SD2112 with 10 HBC μg was statistically significant in comparison to untreated mice (p = 0.035). (D) Administration of either L. paracasei strain NCC 2461 alone or supplemented with anti-rotavirus HBC did not change the diarrhea profile which resembled that of the untreated mice.

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