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Table 2 Processes regulated in colon by Salmonella at days 1, 3 and 6 after oral Salmonella infection

From: Salmonella induces prominent gene expression in the rat colon

Gene Name Gene symbol Sequence ID Fold Change infected vs non-infected rats on different days p.i.
    Time course infection studya Dietary infection studyb
    Day 1 Day 3 Day 6 Day 2
Transport       
Ion transport       
Chloride channel calcium activated 6 Clca6 NM_201419 2,3 2,2 3,7 2,3
Calcium channel, voltage-dependent, alpha 1I subunit Cacna1i NM_020084 2,2 1,5 - 1,2
Solute carrier family 4, member 1 (Slc4a1), anion exchanger Slc4a1 NM_012651 2,0 1,7 - 1,0
Atp-ase, H+/K+ transporting, nongastric, alpha polypeptide Atp12a NM_133517 2,8 - 2,0 1,1
Solute carrier family 20 (phosphate transporter), member 1 Slc20a1 NM_031148 2,1 - - -1,2
Solute carrier family 15 (oligopeptide transporter), member 1 Slc15a1 NM_057121 2,0 1,5 1,6 0,9
Transporter 1, ATP-binding cassette, sub-family B Mdr/Tap1 NM_032055 - 1,8 2,8 1,4
Oxidative stress       
Dual oxidase 2 Duox2 NM_024141 1,9 2,4 2,8 1,6
Glutathione peroxidase 2 Gpx2 NM_183403 - 2,3 3,0 2,2
Xanthine dehydrogenase Xdh NM_017154 - 1,8 2,5 1,4
Immune response       
Rat class III Fc-gamma receptor Fcgr3 M64368 2,1 1,6 - ND
Immunoglobulin superfamily, member 4 Igsf4d XM_340958 2,1 1,6 1,4 1,1
Rat MHC class I truncated cell surface antigen RT1-Aw2 M10094 2,0 - 1,9 1,0
Interleukin enhancer-binding factor 1 Ilf1 XM_221212 2,0 1,5 - 1,1
Colony stimulating factor 2 (granulocyte-macrophage) Csf2 XM_340799 2,0 1,6 - 1,2
Interleukin 1 alpha Il1a NM_017019 1,8 2,0 2,3 1,4
Interleukin 1 beta Il1b NM_031512 - 2,1 4,0 2,6
TRAF2 binding protein T2bp NM_001014044 1,8 2,8 4,4 2,4
Toll-like receptor 2 Tlr2 NM_198769 - 1,5 2,3 1,3
Antimicrobial defense       
Lipopolysaccharide binding protein Lbp NM_017208 1,9 1,8 2,2 1,3
Defensin 5 precursor (Enteric defensin) RD-5 XM_214386 -1,9 -1,6 -1,6 ND
Phospholipase A2, group IIA (platelets, synovial fluid) Pla2g2a NM_031598 3,4 5,2 10,5 7,3
Inflammatory response       
Pancreatitis-associated protein Pap NM_053289 11,4 44,6 114,2 17,7
Tissue-type transglutaminase Tgm2 NM_019386 - 2,3 4,9 1,8
Regenerating islet-derived 3 gamma Reg3g NM_173097 - 2,3 4,3 1,9
Nitric oxide synthase 2, inducible Nos2 NM_012611 - 1,6 4,0 ND
S100 calcium binding protein A8 (calgranulin A) S100a8 NM_053822 - 1,8 2,4 1,4
Calprotectin       
S100 calcium binding protein A9 (calgranulin B) S100a9 NM_053587 - 1,7 1,9 1,3
Interferon       
Interferon-induced guanylate-binding protein 1 Gbp1 XM_221883 2,4 1,9 2,2 1,3
Interferon gamma inducible protein Ifi47 NM_172019 1,7 2,7 7,3 2,6
Guanylate binding protein 2, interferon-inducible Gbp2 NM_133624 1,6 2,4 3,1 1,7
Interferon-induced protein Ifit2 NM_001024753 1,5 1,7 3,4 1,3
Interferon-stimulated protein G1P2 XM_216605 - 1,6 4,1 1,5
Immunity-related GTPase family, M Irgm NM_001012007 - 1,8 3,7 1,4
Signal transducer and activator of transcription 1 Stat1 NM_032612 - 1,7 3,6 1,8
Interferon regulatory factor 7 Irf7 XM_215121 - 1,5 2,6 ND
Alpha-interferon Ifna XM_233145 - 2,0 - ND
Proteolysis       
Ubiquitin D Ubd NM_053299 1,7 2,5 15,2 3,4
Proteosome (prosome, macropain) subunit, beta type 9 Psmb9 NM_012708 - 2,0 3,7 2,0
Protease, serine, 22 Prss22 XM_220222 - 2,0 2,6 1,6
Potential ubiquitin ligase Herc6 XM_342700 - 1,7 3,3 1,5
Proteasome (prosome, macropain) subunit, beta type 10 Psmb10 XM_214687 - 1,5 2,1 1,5
  1. aValues in bold exceed cut-off value FC > 2 or FC < -2. Values -1,5 < FC < 1,5 are indicated by (-).
  2. b Fold Change infected vs non-infected rats fed a cellulose diet at day 2 p.i (obtained from the dietary infection study). All fold changes are shown. Genes not detected in this independent study are indicated by ND.