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Table 6 Chlorpromazine does not inhibit the ability of dopamine to mediate bacterial uptake of Tf-complexed iron.

From: Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica

  Uptake of 55 Fe from 55 Fe-Tf (CPM)
Culture Conditions Y. enterocolitica E. coli S. enterica
No additions (control) 125 (10) 1477 (7) 595 (72)
300 μM Chlorpromazine 231 (3) 1407 (31) 646 (11)
50 μM Dopamine 2083 (120) 24768 (750) 31877 (684)
50 μM Dopamine plus 100 μM Chlorpromazine 2239 (17) 23254 (308) 36937(217)
50 μM Dopamine plus 200 μM Chlorpromazine 2160 (152) 25945 (445) 34934 (638)
50 μM Dopamine plus 300 μM Chlorpromazine 1946 (15) 22434 (17) 33545 (131)
50 μM Dopamine plus 100 μM Fe 932 (11) 4757 (69) 3064 (77)
100 μM Fe 682 (2) 3064 (77) 2783 (28)
  1. The table shows dopamine-mediated bacterial uptake assays of 55Fe from 55Fe-labelled transferrin in the presence of concentrations of chlorpromazine inhibitory to dopamine-mediated growth induction, and were performed as described in the legend to Table 5. The values shown represent the means of bacterial 55Fe incorporation from triplicate 1 ml uptake assays; standard deviations are shown in brackets. There were no significant differences in viable counts between control and test cultures.