PFGE restriction analysis. A: SmaI restriction patterns of four drug clone isolates CHE482, ZH4, ZH43, ZH81 and their corresponding cured strains ME21, ME135, ME138, ME141. The SmaI fragments carrying SCCmec are indicated by filled triangles, and the corresponding fragments of the cured strain are indicated by open triangles. Southern hybridisations using a mecA and a dfrA probe are shown below. B: PFGE patterns of the drug clone CHE482 (filled triangle), its cured strain ME21 (open triangle) and the partially cured strain CHE482Δ (red triangle).