Schematic organisation of the SCCmecN1 of strain CHE482. Primers are indicated by black arrows. Regions coloured in blue represent the core chromosome. Red stars indicate the excision sites of the partially cured strain CHE482Δ. Orange arrows indicate the ISS sites and the internal ISS*. The ccrAB4-1 and ccrAB4-2 complexes are highlighted in light and dark green, respectively. The truncated Tn4003 in orange comprises IS431-orf140-dfrA-thyE-IS431. The class B mec complex in yellow includes mecA- ΔmecR1-IS1272. The fusidic acid resistance gene fusB1 is shown in pink. Dotted lines indicate regions of variability. The region absent in ZH4 and ZH43 is indicated by a dashed line. JL: junction left; JR: junction right. Positions of SCCmec regions J1 and J3 are shown. A: Entire SCCmecN1 in CHE482. B: Partially cured variant CHE482Δ.