Table 1 Scoring system to quantify Haemophilus influenza [NTHi] pathogenicity in the CGS-chinchilla model.
Otologic Score | 0 | 1 | 2 | 3 | 4 | Â |
|---|---|---|---|---|---|---|
Degree of otoscopic changes (inflammation) | None | Mild | Moderate | Frank purulence | Tympanic membrane rupture | Â |
Systemic Score | 0 | 0.5 | 1 | 2 | 3 | 4 |
Systemic description | normal | Slightly lethargic Upright and steady on feet Immediately responds to stimulation by actively moving around cage Eating and drinking | Slightly lethargic Upright and steady on feet Head and ears down Responds by actively moving around cage rapidly when stimulated by voice or touch Eating and drinking Eyes 1/2 open | Moderately lethargic Slightly ataxic Able to keep self upright Moving around cage slowly only when stimulated by voice or touch Eating treats and drinking water | Same as 2 but not eating or drinking Supportive treatment given (fluids and Buprenex) | Extremely lethargic Extremely ataxic Not able to maintain an upright position Barely moving around cage Dyspnea Sacrificed |