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Table 1 Induced P. brasiliensis transcripts potentially related to membrane and cell wall synthesis/remodeling.

From: The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process

Gene Product E.C. number Annotated function Predicted redundancy‡
    M T
Alpha-glucosidase I* (glcase 1) 3.2.1.106 Single glucose residues remotion from oligossaccharides - 1
Phosphoglucomutase (pgm) 5.4.2.8 Synthesis of glucose - 1
UDP-glucose pyrophosphorylase (ugp1) 2.7.7.9 Synthesis of UDP-Glucose - 2
Alpha-1,3 glucan synthase (ags1) 2.4.1.183 Synthesis of α1–3-glucan - 1
Mannitol-1-phosphate dehydrogenase (mtld) 1.1.1.17 Synthesis of fructose 6-phosphate 2 3
Monosaccharide transport protein (mstE) - Low affinity glucose uptake - 1
Sugar transporter protein (stl1) - Uptake of hexoses 3 5
Chitinase 1(cts1) 3.2.1.14 Hydrolysis of chitin 1 2
Chitinase 3* (cts3) 3.2.1.14 Hydrolysis of chitin - 1
Acidic amino acid permease (dip5) - Acidic amino acid uptake 9 9
Histidinol phosphate aminotransferase (hpat) 2.6.1.9 Synthesis of L-histidinol phosphate/glutamate - 1
Malate permease (mael) - Uptake of Malate - 2
UDP-N-acetylglucosamine transporter* (mnn2) - Required for transport of the chitin precursor to Golgi and Endoplasmic reticulum - 1
Glucanosyltransferase family protein (gel) 2.4.1.- Transglucosidase activity 1 3
Rho GTPAse activating protein* (bem3) - Regulation of the beta(1,3)-glucan synthase - 1
Mannosyltransferase (mnt1) 2.4.1.131 Mannosylation of proteins/lipids - 1
Alpha-1,2-mannosyltransferase (mnn5) 2.4.1.131 Mannosylation of proteins/lipids 3 3
Guanosine diphosphatase* (gdA1) 3.6.1.42 Synthesis of GMP - 1
Alpha-1,2 galactosyltransferase* (gma12) 2.4.1.- Galactose incorporation in N- and O-linked mannoproteins - 1
Lysophospholipase (lpb1b) 3.1.1.5 Hydrolysis of phospholipids - 1
Phospholipase A2 (plaA) 3.1.1.4 Hydrolysis of phospholipids - 1
Glycerol-3-phosphate dehydrogenase* (NADP) (gfdA) 1.1.1.94 Synthesis of Glycerol-3-phosphate. - 1
Glycerophosphodiester phosphodiesterase (gpdp) 3.1.4.46 Synthesis of choline and ethanolamine 1 4
Acyl-coenzyme A synthetase (acs) 6.2.1.3 Convertion of the fatty acid to acyl-coA for subsequent beta oxidation - 1
Phosphatidylserine synthase* (pssA) 2.7.8.8 Glycerophospholipid metabolism/Phosphatidylserine synthesis - 1
Myo-inositol-1-phosphate synthase (ino1) 5.5.1.4 Synthesis of myo-inositol 1 phosphate - 1
Phosphatidylinositol transfer protein (pdr16) - Transport of phospholipids from their site of synthesis to cell membranes/Regulator of phospholipid biosynthesis - 1
Lanosterol 14-alpha-demethylase (erg11) 1.14.13.70 Synthesis of ergosterol 3 4
Sterol delta 5,6-desaturase (erg3) 1.3.3.- Regulation of ergosterol biosynthesis - 1
Serine esterase (net1) - Catalysis of the cleavage of fatty acids from membrane lipids - 3
Peroxisomal hydratase dehydrogenase epimerase (hde) 4.2.1.- Beta oxidation - 4
Fatty acid desaturase (desA) 1.14.99.- Insaturation of acyl group of lipids 1 2
Carnitine dehydratase (caiB) 4.2.1.89 Transport of long-chain fatty acids - 1
Suppressor of anucleate metulae B protein* (samB) - Morphogenesis regulation - 1
  1. ‡ The predicted redundancy was obtained from the transition cDNA library in comparison to mycelia transcriptome database [1].
  2. * Novel genes detected in P. brasiliensis.