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Table 1 Induced P. brasiliensis transcripts potentially related to membrane and cell wall synthesis/remodeling.

From: The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process

Gene Product

E.C. number

Annotated function

Predicted redundancy‡

   

M

T

Alpha-glucosidase I* (glcase 1)

3.2.1.106

Single glucose residues remotion from oligossaccharides

-

1

Phosphoglucomutase (pgm)

5.4.2.8

Synthesis of glucose

-

1

UDP-glucose pyrophosphorylase (ugp1)

2.7.7.9

Synthesis of UDP-Glucose

-

2

Alpha-1,3 glucan synthase (ags1)

2.4.1.183

Synthesis of α1–3-glucan

-

1

Mannitol-1-phosphate dehydrogenase (mtld)

1.1.1.17

Synthesis of fructose 6-phosphate

2

3

Monosaccharide transport protein (mstE)

-

Low affinity glucose uptake

-

1

Sugar transporter protein (stl1)

-

Uptake of hexoses

3

5

Chitinase 1(cts1)

3.2.1.14

Hydrolysis of chitin

1

2

Chitinase 3* (cts3)

3.2.1.14

Hydrolysis of chitin

-

1

Acidic amino acid permease (dip5)

-

Acidic amino acid uptake

9

9

Histidinol phosphate aminotransferase (hpat)

2.6.1.9

Synthesis of L-histidinol phosphate/glutamate

-

1

Malate permease (mael)

-

Uptake of Malate

-

2

UDP-N-acetylglucosamine transporter* (mnn2)

-

Required for transport of the chitin precursor to Golgi and Endoplasmic reticulum

-

1

Glucanosyltransferase family protein (gel)

2.4.1.-

Transglucosidase activity

1

3

Rho GTPAse activating protein* (bem3)

-

Regulation of the beta(1,3)-glucan synthase

-

1

Mannosyltransferase (mnt1)

2.4.1.131

Mannosylation of proteins/lipids

-

1

Alpha-1,2-mannosyltransferase (mnn5)

2.4.1.131

Mannosylation of proteins/lipids

3

3

Guanosine diphosphatase* (gdA1)

3.6.1.42

Synthesis of GMP

-

1

Alpha-1,2 galactosyltransferase* (gma12)

2.4.1.-

Galactose incorporation in N- and O-linked mannoproteins

-

1

Lysophospholipase (lpb1b)

3.1.1.5

Hydrolysis of phospholipids

-

1

Phospholipase A2 (plaA)

3.1.1.4

Hydrolysis of phospholipids

-

1

Glycerol-3-phosphate dehydrogenase* (NADP) (gfdA)

1.1.1.94

Synthesis of Glycerol-3-phosphate.

-

1

Glycerophosphodiester phosphodiesterase (gpdp)

3.1.4.46

Synthesis of choline and ethanolamine

1

4

Acyl-coenzyme A synthetase (acs)

6.2.1.3

Convertion of the fatty acid to acyl-coA for subsequent beta oxidation

-

1

Phosphatidylserine synthase* (pssA)

2.7.8.8

Glycerophospholipid metabolism/Phosphatidylserine synthesis

-

1

Myo-inositol-1-phosphate synthase (ino1)

5.5.1.4

Synthesis of myo-inositol 1 phosphate

-

1

Phosphatidylinositol transfer protein (pdr16)

-

Transport of phospholipids from their site of synthesis to cell membranes/Regulator of phospholipid biosynthesis

-

1

Lanosterol 14-alpha-demethylase (erg11)

1.14.13.70

Synthesis of ergosterol

3

4

Sterol delta 5,6-desaturase (erg3)

1.3.3.-

Regulation of ergosterol biosynthesis

-

1

Serine esterase (net1)

-

Catalysis of the cleavage of fatty acids from membrane lipids

-

3

Peroxisomal hydratase dehydrogenase epimerase (hde)

4.2.1.-

Beta oxidation

-

4

Fatty acid desaturase (desA)

1.14.99.-

Insaturation of acyl group of lipids

1

2

Carnitine dehydratase (caiB)

4.2.1.89

Transport of long-chain fatty acids

-

1

Suppressor of anucleate metulae B protein* (samB)

-

Morphogenesis regulation

-

1

  1. ‡ The predicted redundancy was obtained from the transition cDNA library in comparison to mycelia transcriptome database [1].
  2. * Novel genes detected in P. brasiliensis.