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Figure 2 | BMC Microbiology

Figure 2

From: Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity

Figure 2

(A and B) Illustration of the requirement for synergistic activity of both structural components of the lantibiotics lacticin 3147 (LtnA1 and LtnA2) and staphylococcin C55 (C55α and C55β) for full activity of the lantibiotic. C and D illustrate cross complementation of the structural peptides of lacticin 3147 with those of staphylococcin C55. Isobologram graphs show nanomolar concentrations of purified peptides of lacticin 3147 with those of staphylococcin C55. Each point on the graph represents 50% growth inhibition of the indicator L. lactis HP. Isobolograms of (E) represent purified lacticin peptides LtnA1 and LtnA2 titrated against each other, (F) represent purified staphylococcin C55 peptides C55α and C55β titrated against each other, (G) represent purified lacticin LtnA1 peptide titrated against staphylococcin C55β and (H) represent purified staphylococcin C55α titrated against lacticin LtnA2 peptide.

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BMC Microbiology

ISSN: 1471-2180

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