Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections

Table 1 Minimal inhibitory concentrations and minimal bactericidal concentrations of seven potential inhibitors of the YycG histidine kinase

Chemical inhibitor ^a	Minimal inhibitory concentration (MIC, μM)					Minimal bactericidal concentration (MBC, μM)
	S. epidermidis ATCC12228	S. epidermidis RP62A	S. aureus ATCC29213	S. pyogenes 144	S. mutans 128	S. epidermidis ATCC12228	S. epidermidis RP62A
Compound 1	50	50	50	200	>200	200	200
Compound 2	25	25	25	100	100	100	100
Compound 3	12.5	25	100	25	>200	50	100
Compound 4	12.5	12.5	>200	50	>200	50	100
Compound 5	6.25	6.25	6.25	1.56	6.25	25	25
Compound 6	100	100	>200	undone	undone	undone	undone
Compound 7	0.2	>200	>200	>200	>200	>400	>400

^a Stock solution of the compounds were prepared in dimethyl sulfoxide (DMSO) at the concentration of 200 μM. The molecule weights of these seven compounds are: compound 1 (652), compound 2 (519), compound 3 (532), compound 4 (440), compound 5 (623), compound 6 (555) and compound 7 (505).

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