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Table 1 Minimal inhibitory concentrations and minimal bactericidal concentrations of seven potential inhibitors of the YycG histidine kinase

From: Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections

Chemical inhibitor a Minimal inhibitory concentration (MIC, μM) Minimal bactericidal concentration (MBC, μM)
  S. epidermidis
ATCC12228
S. epidermidis
RP62A
S. aureus
ATCC29213
S. pyogenes
144
S. mutans
128
S. epidermidis
ATCC12228
S. epidermidis
RP62A
Compound 1 50 50 50 200 >200 200 200
Compound 2 25 25 25 100 100 100 100
Compound 3 12.5 25 100 25 >200 50 100
Compound 4 12.5 12.5 >200 50 >200 50 100
Compound 5 6.25 6.25 6.25 1.56 6.25 25 25
Compound 6 100 100 >200 undone undone undone undone
Compound 7 0.2 >200 >200 >200 >200 >400 >400
  1. a Stock solution of the compounds were prepared in dimethyl sulfoxide (DMSO) at the concentration of 200 μM. The molecule weights of these seven compounds are: compound 1 (652), compound 2 (519), compound 3 (532), compound 4 (440), compound 5 (623), compound 6 (555) and compound 7 (505).