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Table 4 Drug resistance, cytoskeletal and ion transport proteins showing pH dependence under oxygen limitation

From: Oxygen limitation modulates pH regulation of catabolism and hydrogenases, multidrug transporters, and envelope composition in Escherichia coli K-12

Gene

Function

Log2pH ratio

Acid up-regulated

pH 5.7/pH 7.0

pH 7.0/pH 8.5

pH 5.7/pH 8.5

chaB

Regulator of Na+-Ca+/H+ antiporter

0.80

  

chaC

Regulator of Na+-Ca+/H+ antiporter

0.60

-0.38

 

copA

Copper-, silver-translocating P-type ATPase

0.86

-0.56

 

cueR

Activator of copper-responsive regulon genes cueO and copA

1.31

-0.4

0.91

cusC

Silver and copper efflux

0.44

 

0.63

feoA

ferrous iron transport protein A

 

0.82

1.22

feoB

ferrous iron transport protein B

 

0.41

0.53

marR 1

multiple antibiotic resistance protein

 

0.31

 

mdtE

MdtEF-TolC multidrug resistance efflux transporter

3.17

-1.59

1.58

mdtF

MdtEF-TolC multidrug resistance efflux

2.58

-0.98

1.60

mdtG 1

Multidrug resistance efflux transporter

0.16

 

0.25

mdtI 1

multidrug transport protein

 

1.16

1.16

mdtJ 1

multidrug transport protein

 

2.91

3.02

mdtL

Multidrug resistance efflux protein

  

0.57

mgtA

Mg2+ transport

0.48

 

0.63

nhaA

Na+/H+ antiporter

1.93

-0.93

1.00

nhaB 1

Na+/H+ antiporter

 

0.41

0.37

nikA

periplasmic binding protein for nickel

0.7

 

0.84

nikB

nickel transport

0.50

 

0.56

nikC

nickel transport

0.70

 

0.86

nikD

ATP-binding protein of nickel transport system

0.60

 

0.74

nikE

ATP-binding protein of nickel transport system

0.45

 

0.49

prc

carboxy-terminal protease for penicillin-binding protein 3

0.32

 

0.37

Base up-regulated

acrA

acridine efflux pump

-0.34

-0.35

-0.69

acrB

acridine efflux pump

  

-0.42

acrR 2

acrAB operon repressor

-0.93

 

-1.22

alx 2

Putative metal transporter, homolog of terC (tellurium resistance)

 

-0.57

-0.52

ampC

beta-lactamase; penicillin resistance; penicillin-binding protein

-0.24

 

-0.12

atpA 2

ATP synthase, F1 alpha-subunit

  

-0.66

atpC 2

ATP synthase, F1 epsilon-subunit

  

-0.66

atpD 2

ATP synthase, F1 beta-subunit

-0.35

-0.36

-0.71

atpF 2

ATP synthase, F0 subunit b

 

-0.46

-0.51

atpG 2

ATP synthase, F1 gamma-subunit

  

-0.66

atpH 2

ATP synthase, F1 delta-subunit

 

-0.42

-0.58

atpI 2

ATP synthase subunit

  

-0.53

chaA

Na+-Ca+/H+ antiporter

 

-0.86

-1.1

corA

Mg2+ transport, system I

0.10

 

-0.39

cutA

divalent cation tolerance protein

-0.27

 

-0.3

dacA

D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5

-0.58

 

-0.65

dacC

D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6

0.87

-1.16

 

dacD

penicillin binding protein 6b

-1.22

 

-0.90

emrA 1

multidrug resistance secretion protein

-0.64

 

-0.11

mepA 1

murein DD-endopeptidase, penicillin-insensitive

-0.68

 

-0.19

mreB 2

regulator of ftsI, penicillin binding protein 3, septation function

-0.53

 

-0.44

mreC

rod shape-determining protein

-0.29

 

-0.39

napF

Fe-S ferredoxin-type protein

-0.59

 

-0.14

napG

ferredoxin-type protein

-0.39

 

-0.20

napH

ferredoxin-type protein

-0.37

 

-0.20

  1. 1Acid up-regulated with aeration [2]
  2. 2Base up-regulated with aeration [2]