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Table 4 Drug resistance, cytoskeletal and ion transport proteins showing pH dependence under oxygen limitation

From: Oxygen limitation modulates pH regulation of catabolism and hydrogenases, multidrug transporters, and envelope composition in Escherichia coli K-12

Gene Function Log2pH ratio
Acid up-regulated pH 5.7/pH 7.0 pH 7.0/pH 8.5 pH 5.7/pH 8.5
chaB Regulator of Na+-Ca+/H+ antiporter 0.80   
chaC Regulator of Na+-Ca+/H+ antiporter 0.60 -0.38  
copA Copper-, silver-translocating P-type ATPase 0.86 -0.56  
cueR Activator of copper-responsive regulon genes cueO and copA 1.31 -0.4 0.91
cusC Silver and copper efflux 0.44   0.63
feoA ferrous iron transport protein A   0.82 1.22
feoB ferrous iron transport protein B   0.41 0.53
marR 1 multiple antibiotic resistance protein   0.31  
mdtE MdtEF-TolC multidrug resistance efflux transporter 3.17 -1.59 1.58
mdtF MdtEF-TolC multidrug resistance efflux 2.58 -0.98 1.60
mdtG 1 Multidrug resistance efflux transporter 0.16   0.25
mdtI 1 multidrug transport protein   1.16 1.16
mdtJ 1 multidrug transport protein   2.91 3.02
mdtL Multidrug resistance efflux protein    0.57
mgtA Mg2+ transport 0.48   0.63
nhaA Na+/H+ antiporter 1.93 -0.93 1.00
nhaB 1 Na+/H+ antiporter   0.41 0.37
nikA periplasmic binding protein for nickel 0.7   0.84
nikB nickel transport 0.50   0.56
nikC nickel transport 0.70   0.86
nikD ATP-binding protein of nickel transport system 0.60   0.74
nikE ATP-binding protein of nickel transport system 0.45   0.49
prc carboxy-terminal protease for penicillin-binding protein 3 0.32   0.37
Base up-regulated
acrA acridine efflux pump -0.34 -0.35 -0.69
acrB acridine efflux pump    -0.42
acrR 2 acrAB operon repressor -0.93   -1.22
alx 2 Putative metal transporter, homolog of terC (tellurium resistance)   -0.57 -0.52
ampC beta-lactamase; penicillin resistance; penicillin-binding protein -0.24   -0.12
atpA 2 ATP synthase, F1 alpha-subunit    -0.66
atpC 2 ATP synthase, F1 epsilon-subunit    -0.66
atpD 2 ATP synthase, F1 beta-subunit -0.35 -0.36 -0.71
atpF 2 ATP synthase, F0 subunit b   -0.46 -0.51
atpG 2 ATP synthase, F1 gamma-subunit    -0.66
atpH 2 ATP synthase, F1 delta-subunit   -0.42 -0.58
atpI 2 ATP synthase subunit    -0.53
chaA Na+-Ca+/H+ antiporter   -0.86 -1.1
corA Mg2+ transport, system I 0.10   -0.39
cutA divalent cation tolerance protein -0.27   -0.3
dacA D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 -0.58   -0.65
dacC D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6 0.87 -1.16  
dacD penicillin binding protein 6b -1.22   -0.90
emrA 1 multidrug resistance secretion protein -0.64   -0.11
mepA 1 murein DD-endopeptidase, penicillin-insensitive -0.68   -0.19
mreB 2 regulator of ftsI, penicillin binding protein 3, septation function -0.53   -0.44
mreC rod shape-determining protein -0.29   -0.39
napF Fe-S ferredoxin-type protein -0.59   -0.14
napG ferredoxin-type protein -0.39   -0.20
napH ferredoxin-type protein -0.37   -0.20
  1. 1Acid up-regulated with aeration [2]
  2. 2Base up-regulated with aeration [2]