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Table 3 gad regulon components showing pH dependence under oxygen limitation.

From: Oxygen limitation modulates pH regulation of catabolism and hydrogenases, multidrug transporters, and envelope composition in Escherichia coli K-12

Gene Function Log2 Expression ratio
   pH 5.7/pH 7.0 pH 7.0/pH 8.5 pH 5.7/pH 8.5
GadA region: 3650–3666 kb    
slp Outer membrane protein induced after carbon starvation 3.47 -1.82 1.64
dctR Probable repressor of dctA dicarboxylate transporter gene 2.60 -1.00 1.59
yhiD integral membrane protein related to MgtC. 2.26 -1.04 1.21
hdeB Periplasmic chaperone of acid-denatured proteins 0.79 -0.55  
hdeA Periplasmic chaperone of acid-denatured proteins 0.74 -0.50  
hdeD Putative membrane transporter, H-NS repressed 2.30 -1.26 1.03
gadE Required for stationary phase-induced, pH 5.5 growth medium-induced, and EvgA-induced acid resistance 3.19 -2.23 0.95
mdtE MdtEF-TolC multidrug resistance efflux RND-type transporter; overexpression resistance to erythromycin, deoxycholate, octane and rhodamine 3.17 -1.59 1.58
mdtF MdtEF-TolC multidrug resistance efflux RND-type transporter; overexpression resistance to erythromycin, deoxycholate, octane and rhodamine 2.58 -0.98 1.60
gadW Positive AraC-type regulator of gadA and gadBC, in absence of gadX; repressor of gadX 2.70 -1.17 1.53
gadY sRNA regulates gadX and gadY 3.17 -1.38 1.80
gadX Positive transcriptional regulator of gadA and gadBC; repressed by HNS and GadW; stimulated by RpoS 2.66 -1.47 1.19
gadA Glutamate decarboxylase isozyme 4.89 -3.46 1.43
GadB operon: 1567–1570 kb    
gadB Glutamate decarboxylase isozyme 3.21 -2.50  
gadC Glutamate transporter 3.73 -2.44 1.29