Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups

Table 3 Positively selected sites identified by Codeml program and REL in DataMonkey package.

Domains	Positively selected sites in different epidemic groups
	02–04 interspecies	03-early-mid	03-late
S1	78 113 139 147 227 239 261 336 425 462 472 479 480 558 607 608 609 613	49 75 77 144 239 244 311 344	None
S2	701 714 743 754 765 856 894	778 860 861 1001 1148 1163 1179 1247	None

Positively selected sites identified by program Codeml at the level of posterior probability ≥ 0.95 are shown in boldface. The underlines represent the sites locating in receptor-binding domain (RBD) (residues: 318–510) of S1 domain or in heptad repeat (HR)1 (residues: 889–972)-HR2 (residues: 1142–1185) region of S2 domain.

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