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Table 3 Positively selected sites identified by Codeml program and REL in DataMonkey package.

From: Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups

Domains Positively selected sites in different epidemic groups
  02–04 interspecies 03-early-mid 03-late
S1 78 113 139 147 227 239 261 336 425 462 472 479 480 558 607 608 609 613 49 75 77 144 239 244 311 344 None
S2 701 714 743 754 765 856 894 778 860 861 1001 1148 1163 1179 1247 None
  1. Positively selected sites identified by program Codeml at the level of posterior probability ≥ 0.95 are shown in boldface. The underlines represent the sites locating in receptor-binding domain (RBD) (residues: 318–510) of S1 domain or in heptad repeat (HR)1 (residues: 889–972)-HR2 (residues: 1142–1185) region of S2 domain.