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Table 5 Effect of efflux on MICs of Brucella reference strains for erythromycin and clindamycin.

From: Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications

Brucella

MIC

 

Ery

Ery + PAβN

CL

CL + PAβN

B. ab b1

>256

96

>256

96

B. ab b2

0.19

0.0275

3

0.25

B. ab b3

128

64

192

128

B. ab b4

128

64

192

64

B. ab b5

>256

192

128

128

B. ab b6

>256

256

>256

96

B. ab b9

>256

>256

>256

>256

B. mel b1

16

4

24

16

B. mel b2

>256

48

64

12

B. mel b3

256

48

64

32

B. suis b1

1.5

0.75

8

4

B. suis b2

0.125

0.032

3

0.047

B. suis b3

1.5

1.0

24

48

B. suis b4

2

1.5

24

32

B. suis b5

0.094

0.047

6

2

B. canis

0.50

0.094

8

0.50

B. ovis

0.064

<0.016

3

<0.016

B. neo

0.75

0.047

3

0.75

Porpoise

1.5

0.25

16

3

Seal

6

1.5

>256

48

Dolphin

3

0.38

2

0.75

  1. Brucella strains are as listed in Table 1; MIC, minimum inhibitory concentration; Ery, erythromycin; CL, clindamycin; PAβN, efflux inhibitor L-phenylalanine-L-arginine β-naphthylamide; b, biovar; ab, abortus; mel, melitensis; neo, neotomae.
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BMC Microbiology

ISSN: 1471-2180

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