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Table 5 Effect of efflux on MICs of Brucella reference strains for erythromycin and clindamycin.

From: Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications

Brucella MIC
  Ery Ery + PAβN CL CL + PAβN
B. ab b1 >256 96 >256 96
B. ab b2 0.19 0.0275 3 0.25
B. ab b3 128 64 192 128
B. ab b4 128 64 192 64
B. ab b5 >256 192 128 128
B. ab b6 >256 256 >256 96
B. ab b9 >256 >256 >256 >256
B. mel b1 16 4 24 16
B. mel b2 >256 48 64 12
B. mel b3 256 48 64 32
B. suis b1 1.5 0.75 8 4
B. suis b2 0.125 0.032 3 0.047
B. suis b3 1.5 1.0 24 48
B. suis b4 2 1.5 24 32
B. suis b5 0.094 0.047 6 2
B. canis 0.50 0.094 8 0.50
B. ovis 0.064 <0.016 3 <0.016
B. neo 0.75 0.047 3 0.75
Porpoise 1.5 0.25 16 3
Seal 6 1.5 >256 48
Dolphin 3 0.38 2 0.75
  1. Brucella strains are as listed in Table 1; MIC, minimum inhibitory concentration; Ery, erythromycin; CL, clindamycin; PAβN, efflux inhibitor L-phenylalanine-L-arginine β-naphthylamide; b, biovar; ab, abortus; mel, melitensis; neo, neotomae.