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Figure 2 | BMC Microbiology

Figure 2

From: M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression

Figure 2

M. leprae induces a lower rate of cell death as compared with BCG. THP-1 cells were infected with M. leprae and BCG as described in Fig. 1. A. Cellular viability was assessed after fluorescent staining at 18 and 48 h post-infection. Graphs show the results from 5 independent experiments with SD shown as 'y' error bar. '*' denotes significant differences (P < 0.05). (i) M. leprae, (ii) BCG. B. Agarose gel electrophoresis of internucleosomal DNA fragmentation in THP-1 cells shows spontaneous (lane 1), or BCG-induced apoptosis at MOI-10 (lane 2) and MOI-20 (lane 3) after 18 h of culture. The molecular markers are indicated to the left (lane M).

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