Table 2 Genes downregulated at least twofold at 37°C relative to 28°

pathogenic genes

LA1029

Sphingomyelinase C precursor

0.318

0.181

Cell wall/membrane biogenesis genes

LA2248

putative outer membrane protein

0.473

0.405

LA2200

putative N-acetylmuramoyl-L-alanine amidase

0.20

0.278

LA4232

conserved hypothetical protein

0.413

0.383

LA1404

putative outer membrane protein

0.394

0.350

Posttranslational modification, heat shock proteins genes

LA3562

conserved hypothetical protein

0.457

0.450

replication, DNA repair, transcription and translation genes

LB112

putative regulatory protein contains GAF domain

0.491

0.395

LB367

hypothetical protein

0.414

0.285

LA2774

conserved hypothetical protein

0.380

0.423

LA4236

MutS-like mismatch repair protein, ATPases

0.297

0.265

LA3011

Cell division protein ftsK homologue

0.397

0.469

LA0937

hypothetical protein

0.447

0.429

LA3419

DNA-directed RNA polymerase, beta subunit

0.327

0.37

Signal transduction mechanism genes

LA1483

GGDEF domain protein

0.481

0.456

LA2423

two-component response regulator

0.479

0.471

LA2426

Methyl-accepting chemotaxis protein

0.260

0.197

LA2427

Chemotaxis protein chew

0.450

0.335

LA2434

probable anti-sigma factor antagonist

0.483

0.378

LA3107

unknown protein

0.185

0.153

LB112

putative regulatory protein contains GAF domain

0.491

0.395

LA3950

hypothetical protein

0.462

0.465

LA3357

Sensory transduction histidine kinase

0.465

0.474

LA4104

two-component hybrid sensor and regulator

0.455

0.450

Chemotaxis and flagellar genes

LA2426

Methyl-accepting chemotaxis protein

0.260

0.197

LA2427

Chemotaxis protein chew

0.450

0.335

metabolism genes

LA0106

long-chain-fatty-acid CoA ligase

0.463

0.442

LA0828

Acetyl-CoA acetyl transferases

0.469

0.332

LA1430

3-oxoacyl-[acyl-carrier-protein] synthase

0.493

0.356

LA2008

hydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

0.469

0.332

LA2009

pyruvate dehydrogenase E1 component, beta subunit

0.451

0.371

LA2010

pyruvate dehydrogenase E1 component, alpha subunit

0.486

0.435

LA1485

mRNA-binding proteins

0.278

0.436

LA2724

hypothetical protein

0.116

0.320

LA3168

hypothetical protein

0.280

0.230

LA4176

conserved hypothetical protein

0.480

0.448

LA4233

hypothetical protein

0.294

0.190

LA3312

glyoxalase

0.497

0.436

LA3628

anthranilate synthase component I

0.364

0.403

LA3998

cholesterol oxidase

0.381

0.358

LA4349

putative peptidase

0.437

0.349

LB093

probable long-chain-fatty-acid – CoA ligase

0.338

0.296

general function

LA0827

hypothetical protein

0.332

0.410

LA1920

RNA-binding protein

0.301

0.0823

LA2724

hypothetical protein

0.116

0.320

LA3168

hypothetical protein

0.280

0.230

LA3400

processing proteinase

0.350

0.491

LA3998

cholesterol oxidase

0.381

0.358

LB265

conserved hypothetical protein

0.369

0.376

LA3584

TPR-repeat-containing protein

0.0539

0.159

unknown

LA0091

conserved hypothetical protein

0.444

0.441

LA2259

conserved hypothetical protein

0.362

0.358

LA3196

conserved hypothetical protein

0.239

0.200

LA1031

hypothetical protein

0.223

0.476

LA0278

hypothetical protein

0.0698

0.376

LA1403

hypothetical protein

0.252

0.233

LA1468

conserved hypothetical protein

0.286

0.316

LA1572

conserved hypothetical protein

0.391

0.359

LA1910

hypothetical protein

0.452

0.495

LA1973

hypothetical protein

0.399

0.398

LA2020

hypothetical protein

0.260

0.177

LA2624

hypothetical protein

0.462

0.472

LA2859

unknown protein

0.401

0.358

LA2946

hypothetical protein

0.370

0.103

LA3036

hypothetical protein

0.363

0.480

LA3083

hypothetical protein

0.412

0.272

LA3344

hypothetical protein

0.123

0.184

LA3452

hypothetical protein

0.326

0.378

LA4030

hypothetical protein

0.469

0.350

LA4046

hypothetical protein

0.490

0.450

LA4282

hypothetical protein

0.454

0.420

LB032

hypothetical protein

0.422

0.485

LB217

hypothetical protein

0.442

0.324

LB217

hypothetical protein

0.324

0.442

LB243

hypothetical protein

0.375

0.448

LB316

unknown protein

0.345

0.290

LA1178

hypothetical protein

0.188

0.432

LA1306

hypothetical protein

0.395

0.388

LA1952

hypothetical protein

0.440

0.419

LA2013

hypothetical protein

0.262

0.243

LA2624

hypothetical protein

0.111

0.158

LA2720

hypothetical protein

0.190

0.458

LA2839

hypothetical protein

0.233

0.346

LA4095

hypothetical protein

0.377

0.341

LA1800

Hypothetical protein

0.485

0.242