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Table 2 Genes downregulated at least twofold at 37°C relative to 28°

From: Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601

Gene ID Gene function and name Fold change in
   Expt1 Expt2
pathogenic genes
LA1029 Sphingomyelinase C precursor 0.318 0.181
Cell wall/membrane biogenesis genes
LA2248 putative outer membrane protein 0.473 0.405
LA2200 putative N-acetylmuramoyl-L-alanine amidase 0.20 0.278
LA4232 conserved hypothetical protein 0.413 0.383
LA1404 putative outer membrane protein 0.394 0.350
Posttranslational modification, heat shock proteins genes
LA3562 conserved hypothetical protein 0.457 0.450
replication, DNA repair, transcription and translation genes
LB112 putative regulatory protein contains GAF domain 0.491 0.395
LB367 hypothetical protein 0.414 0.285
LA2774 conserved hypothetical protein 0.380 0.423
LA4236 MutS-like mismatch repair protein, ATPases 0.297 0.265
LA3011 Cell division protein ftsK homologue 0.397 0.469
LA0937 hypothetical protein 0.447 0.429
LA3419 DNA-directed RNA polymerase, beta subunit 0.327 0.37
Signal transduction mechanism genes
LA1483 GGDEF domain protein 0.481 0.456
LA2423 two-component response regulator 0.479 0.471
LA2426 Methyl-accepting chemotaxis protein 0.260 0.197
LA2427 Chemotaxis protein chew 0.450 0.335
LA2434 probable anti-sigma factor antagonist 0.483 0.378
LA3107 unknown protein 0.185 0.153
LB112 putative regulatory protein contains GAF domain 0.491 0.395
LA3950 hypothetical protein 0.462 0.465
LA3357 Sensory transduction histidine kinase 0.465 0.474
LA4104 two-component hybrid sensor and regulator 0.455 0.450
Chemotaxis and flagellar genes
LA2426 Methyl-accepting chemotaxis protein 0.260 0.197
LA2427 Chemotaxis protein chew 0.450 0.335
metabolism genes
LA0106 long-chain-fatty-acid CoA ligase 0.463 0.442
LA0828 Acetyl-CoA acetyl transferases 0.469 0.332
LA1430 3-oxoacyl-[acyl-carrier-protein] synthase 0.493 0.356
LA2008 hydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex 0.469 0.332
LA2009 pyruvate dehydrogenase E1 component, beta subunit 0.451 0.371
LA2010 pyruvate dehydrogenase E1 component, alpha subunit 0.486 0.435
LA1485 mRNA-binding proteins 0.278 0.436
LA2724 hypothetical protein 0.116 0.320
LA3168 hypothetical protein 0.280 0.230
LA4176 conserved hypothetical protein 0.480 0.448
LA4233 hypothetical protein 0.294 0.190
LA3312 glyoxalase 0.497 0.436
LA3628 anthranilate synthase component I 0.364 0.403
LA3998 cholesterol oxidase 0.381 0.358
LA4349 putative peptidase 0.437 0.349
LB093 probable long-chain-fatty-acid – CoA ligase 0.338 0.296
general function
LA0827 hypothetical protein 0.332 0.410
LA1920 RNA-binding protein 0.301 0.0823
LA2724 hypothetical protein 0.116 0.320
LA3168 hypothetical protein 0.280 0.230
LA3400 processing proteinase 0.350 0.491
LA3998 cholesterol oxidase 0.381 0.358
LB265 conserved hypothetical protein 0.369 0.376
LA3584 TPR-repeat-containing protein 0.0539 0.159
unknown
LA0091 conserved hypothetical protein 0.444 0.441
LA2259 conserved hypothetical protein 0.362 0.358
LA3196 conserved hypothetical protein 0.239 0.200
LA1031 hypothetical protein 0.223 0.476
LA0278 hypothetical protein 0.0698 0.376
LA1403 hypothetical protein 0.252 0.233
LA1468 conserved hypothetical protein 0.286 0.316
LA1572 conserved hypothetical protein 0.391 0.359
LA1910 hypothetical protein 0.452 0.495
LA1973 hypothetical protein 0.399 0.398
LA2020 hypothetical protein 0.260 0.177
LA2624 hypothetical protein 0.462 0.472
LA2859 unknown protein 0.401 0.358
LA2946 hypothetical protein 0.370 0.103
LA3036 hypothetical protein 0.363 0.480
LA3083 hypothetical protein 0.412 0.272
LA3344 hypothetical protein 0.123 0.184
LA3452 hypothetical protein 0.326 0.378
LA4030 hypothetical protein 0.469 0.350
LA4046 hypothetical protein 0.490 0.450
LA4282 hypothetical protein 0.454 0.420
LB032 hypothetical protein 0.422 0.485
LB217 hypothetical protein 0.442 0.324
LB217 hypothetical protein 0.324 0.442
LB243 hypothetical protein 0.375 0.448
LB316 unknown protein 0.345 0.290
LA1178 hypothetical protein 0.188 0.432
LA1306 hypothetical protein 0.395 0.388
LA1952 hypothetical protein 0.440 0.419
LA2013 hypothetical protein 0.262 0.243
LA2624 hypothetical protein 0.111 0.158
LA2720 hypothetical protein 0.190 0.458
LA2839 hypothetical protein 0.233 0.346
LA4095 hypothetical protein 0.377 0.341
LA1800 Hypothetical protein 0.485 0.242