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Table 1 Analysis of the giardial PI3K domains. Percentage identity values for the full-length and domain-only sequences of GiPI3K1 and GiPI3K2 with other PI3K isoforms following their sequence alignment.

From: Evidence from bioinformatics, expression and inhibition studies of phosphoinositide-3 kinase signalling in Giardia intestinalis

  GiPI3K1 GiPI3K2
Full- length 39% to Dictyostelium discoideum PIK1, a Class I PI3K 34% to Glycine max Vps34-like (Class III) PI3K
Ras Binding Domain (RBD) 41% to Homo sapiens Class IB p110γ PI3K Absent
PIK 28% to H. sapiens Class IA p110α PI3K 27% to Caenorhabditis elegans Vps34-like (Class III) PI3K
Kinase 39% to D. discoideum PIK1 33% to Glycine max Vps34-like (Class III) PI3K