Domain structure of GiPI3K1 and GiPI3K2 compared with other PI3Ks. Top: GiPI3K1 is compared to Dd PIK1, Dictyostelium discoideum Class I PI3K [GenPept: AAA85721] and to Hs p110γ, Homo sapiens Class I PI3K [GenPept: NP_002640]. The GiPI3K1 sequence is interrupted for the sake of clarity. Bottom: GiPI3K2 is compared to Gm PI3K, Glycine max Class III PI3K [GenPept: AAA64468] and to Sp Vps34, Schizosaccharomyces pombe Class III PI3K [GenPept: AAC49133]. Numbers indicate amino acids. Domains are shaded as follows: checked, Ras binding; dotted, C2; striped, PIK; gradient, kinase. Apparent insertions in the giardial kinase domains are indicated by a dotted line.