A: LlaJI and its identified homologous restriction modification systems. Genes sharing protein sequence homology to LlaJI components are linked by shading (with the percentages representative of the respective identity to LlaJI). B: Alignment of R1.LlaJI with is identified homologues. The aligned regions correspond to a section containing the three conserved motif's (indicated above each on the alignment) which comprise the predicted GTP binding and hydrolysis domain. Motif II for McrB is underlined. Additional conserved modules in this region are indicated by dashed lines above each. C: Alignment of the section of R2.LlaJI and its identified homologues predicted to contain the catalytic centre. The conserved PD...Xn....(D/E)XK motif is indicated.