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Table 2 Km of PDEs

From: Cyclic nucleotide specific phosphodiesterases of Leishmania major

PDE

cAMP (μM)

cGMP (μM)

Refs

LmPDEB1

0.99

---

*)

LmPDEB2

6.98

---

*)

TbrPDEB1/TbPDE2C

7.97

---

[20]

TbrPDEB2/TbPDE2B

2.4

---

[21]

HsPDE1A1

112.7

5.0

[38]

HsPDE1B1

24.3

2.7

[38]

HcPDE1C2

1.2

1.1

[38]

HsPDE2

30 – 50

15 – 30

[38]

HsPDE3

0.1–0.8

0.1– 0.8

[38]

HsPDE4

1 – 3

---

[38]

HsPDE5

> 300

1 – 5

[38]

HsPDE6

910

14

[39]

HsPDE7

0.2 – 1

---

[38]

HsPDE8

0.06 – 0.15

124

[38]

HsPDE9

320

0.007–0.17

[38]

HsPDE10

0.05

3

[38]

HsPDE11

0.5

1

[38]

  1. *) this work