Table 1 Amino acid replacements of conserved residues in the catalytic domains of L. major PDEs. Amino acid conservation is indicated by a dash.
From: Cyclic nucleotide specific phosphodiesterases of Leishmania major
HsPDE4B | Y399 | H406 | N407 | H410 | H446 | D447 | H450 | G452 | A466 | E476 | H478 | H479 | T517 | D564 | E585 | Q615 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LmjPDEA | - | - | - | - | - | - | - | - | - | - | L459 | - | - | - | - | - |
LmjPDEB1 | - | - | - | - | - | - | - | - | G741 | - | - | - | - | - | - | - |
LmjPDEB2 | - | - | - | - | - | - | - | - | G731 | - | - | - | - | - | - | - |
LmjPDEC | - | - | - | - | - | - | - | - | Y673 | - | M685 | - | - | - | - | - |
LmjPDED | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |