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Table 1 Amino acid replacements of conserved residues in the catalytic domains of L. major PDEs. Amino acid conservation is indicated by a dash.

From: Cyclic nucleotide specific phosphodiesterases of Leishmania major

HsPDE4B Y399 H406 N407 H410 H446 D447 H450 G452 A466 E476 H478 H479 T517 D564 E585 Q615
LmjPDEA - - - - - - - - - - L459 - - - - -
LmjPDEB1 - - - - - - - - G741 - - - - - - -
LmjPDEB2 - - - - - - - - G731 - - - - - - -
LmjPDEC - - - - - - - - Y673 - M685 - - - - -
LmjPDED - - - - - - - - - - - - - - - -