Sequence organization and comparison of LmjPDEB1 and LmjPDEB2. Panel A: Extent of amino acid sequence identity between various parts of LmjPBEB1 and LmjPDEB2. A 24 amino acid stretch within the otherwise identical catalytic region is entirely dissimilar between the two. Panel B: similar stretches of sequence divergence (boxed area) are found at identical positions within the otherwise highly conserved catalytic regions the T. brucei and T. cruzi homologues. 1: TbrPDEB1; 2: TbrPDEB2; 3: LmjPDEB1; 4: LmjPDEB2; 5: TcrPDEB1; 6: TcrPBEB2.