Intracellular trafficking, secretion, and vesicular transport
|
I
|
1894
|
Gramicidin S biosynthesis
|
grsT
|
S
|
-0.4
|
1.5
|
0.9
|
II
|
0029–30
|
VirB5-B6
|
virB5/6
|
S
| | | |
II
|
0034
|
Type IV secretion (channel protein)
|
virB10
|
S
| |
2.5*
| |
II
|
0035
|
Type IV secretion (ATPase)
|
virB11
|
S
| |
2.3***
| |
Nucleotide transport and metabolism
|
I
|
0233
|
Phosphoribosylaminoimidazolecarboxamide formyltransfease
|
purH
|
S
|
0.4
|
0.9
| |
I
|
0295
|
Phosphoribosylaminoimidazole carboxylase ATPase subunit
|
purK
|
S
|
0.3
|
0.9
| |
I
|
1123
|
Phosphoribosylformylglycinamidine (FGAM) synthase
|
purS
|
S
|
0.9
|
2.9
| |
I
|
1124
|
Phosphoribosylformylglycinamidine (FGAM) synthase
|
purQ
|
S
|
1.9
|
2.2
| |
I
|
1204
|
Exopolyphosphatase (Ppx/GppA)
|
ppx
|
S
|
0.4
|
1.2
| |
Signal transduction mechanisms
|
I
|
0066
|
Response regulator (two component)
|
ompR
|
S
|
0.6
|
1.3
|
1.9*
|
I
|
1327
|
Glutamate-ammonia-ligase adenylyltransferase (signal transduction)
|
glnE
|
S
|
-0.1
|
1.2
|
1.4
|
I
|
1807
|
Universal stress protein
|
uspA
|
S
| |
0.4
|
0.1
|
Transcription
|
I
|
0304/5
|
Hypothetical thioesterase-transcriptional regulator
|
deoR
|
S
|
-0.5
|
1.9
| |
I
|
0371
|
Regulatory factor (rpoE)
|
virF
|
S
|
-0.1
|
1.1
|
0.3
|
I
|
0508
|
Transcription elongation factor
|
greA
|
S
|
1.0
|
0.7
|
0.6
|
I
|
0513
|
Transcription factor
|
lysR
|
S
| |
0.9
| |
I
|
0513/4
|
Transcription factor-hypothetical protein
|
lysR/hyp
|
S
|
0.2
|
0.7
| |
I
|
0731/2
|
Cold shock protein-hypothetical cytosolic protein
|
csp/hyp
|
S
|
0.2
|
1.1
|
0.9
|
I
|
0808
|
Transcriptional regulator (soxR)
|
merR
|
S
|
1.0
|
0.8
| |
I
|
1178
|
Transcriptional regulator (soxR)
|
merR
|
S
|
0.0
| | |
I
|
1297/8
|
RNA polymerase omega subunit-hypothetical protein
|
rpoZ/hyp
|
S
|
0.2
|
1.3
| |
I
|
1364
|
Transcriptional regulatory protein
|
mucR
|
S
|
0.3
|
2.0***
|
3.0**
|
I
|
1647/8
|
Hyp-RegM (ATP-binding)
|
hyp/regM
|
S
| |
1.0
|
-0.2
|
II
|
1116/7
|
Transcriptional activator LuxR-TetR families
|
luxR/tetR
|
S
|
0.1
|
1.6**
|
1.1
|
Cell wall/membrane/envelope biogenesis
|
I
|
0498/9
|
Cold shock protein/soluble lytic transglycosylase
|
cspA/slt
|
R
|
0.0
|
1.7***
|
2.9
|
I
|
1302
|
Soluble lytic murein transglycosylase
|
mltE
|
R
|
0.6
|
0.7
|
0.4
|
I
|
1415
|
O-antigen export system permease protein
|
rfbD
|
R
|
0.1
|
1.3
| |
I
|
1416
|
O-antigen export system ATP-binding protein
|
rfbE
|
R
|
0.3
|
1.9**
| |
I
|
1427
|
UDP-N-acetylglucosamine 4,6-dehydratase
|
capD
|
R
|
-0.3
|
1.4
| |
II
|
0380
|
Acriflavin resistance protein A (membrane biogenesis)
|
acrA(hlyD)
|
S
| |
3.4
| |
II
|
0472
|
Membrane fusion protein (membrane biogenesis)
|
mtrC(hlyD)
|
S
|
0.9
|
0.3
| |
Energy production and conversion
|
I
|
0972
|
Glutathione reductase
|
gor
|
S
|
0.3
|
0.5
| |
I
|
1749
|
FAD-dependent glycerol phosphate dehydrogenase
|
glpD
|
S
|
0.2
|
0.7
| |
Amino acid transport and metabolism
|
II
|
0285
|
Dipeptide transport system (inner membrane permease)
|
dppB
|
S
| |
0.4
|
0.7
|
Replication, recombination and repair
|
I
|
0334
|
AAA ATPase/DNA helicase/DNA damage checkpoint
|
ruvB
|
S
|
1.3
|
0.9
| |
I
|
1307
|
Integrase/recombinase (phage)
|
xerC (int)
|
S
|
0.1
|
1.1
| |
I
|
2023
|
ATP-dependent nuclease subunit A
|
uvrD/rep
|
S
| |
0.9
| |
II
|
0260
|
GTP-binding protein
|
lepA
|
S
|
0.9
|
0.1
| |
I
|
1296
|
GTP-binding protein
|
lepA
|
S
| |
1.0
| |
Translation, ribosome structure and biogenesis
|
I
|
0983
|
Ribosomal large subunit pseudouridine synthase C
|
rluA
|
S
|
0.5
|
1.1
|
1.0
|
I
|
1057
|
Ribonuclease E/Zn metalloprotease
|
cafA
|
S
|
0.5
|
1.1
|
1.6
|
I
|
1775–6
|
Rnase PH-HrcA (heat shock protein repressor)
|
rph/hrcA
|
S
|
-0.2
|
1.0
|
0.6
|
Function unknown
|
I
|
0186
|
Hypothetical cytosolic protein
|
dut
|
S
|
0.6
|
0.4
| |
I
|
0193
|
Hypothetical protein
|
hyp
|
S
|
0.4
|
2.4
|
1.5
|
I
|
0490
|
Hypothetical cytosolic protein
|
hycp
|
S
|
0.6
|
0.6
| |
I
|
0540
|
Hypothetical protein
|
hyp
|
S
|
0.0
|
0.6
| |
I
|
0603
|
Hypothetical protein
|
hyp
|
S
|
-0.1
|
1.1
| |
I
|
0732
|
Hypothetical cytosolic protein
|
hycp
|
S
| |
1.4
| |
II
|
0045–6
|
Hypothetical protein-Hypothetical protein
|
hyp/hyp
|
S
| | | |
Posttranslational modification, protein turnover and chaperones
|
I
|
0816
|
ATP-dependent clp protease ATP-binding subunit
|
clpA
|
S
|
1.0
|
0.8
|
1.5
|
II
|
0932
|
Glutaredoxin
|
nrdH
|
S
| |
1.1
|
-0.3
|
Defense mechanisms
|
I
|
0926
|
Multidrug resistance locus
|
emrA
| | |
2.2
| |
General function prediction
|
I
|
1143
|
Metal-dependent hydrolase (β-lactamase)
|
mbl
|
S
|
-0.1
|
0.9
| |
I
|
1282
|
Glycine cleavage T protein (aminomethyltransferase)
|
gcvT
|
S
|
1.2
|
0.4
| |
I
|
1487
|
Colicin V production protein
|
colV
|
S
|
1.2
|
0.5
|
0.8
|
I
|
1499
|
Pirin (cupin)
|
pirA
|
S
|
-0.1
|
1.3
|
1.7
|
I
|
1867
|
Florfenicol resistance protein
|
nifB/elp3
|
S
|
0.4
|
0.5
| |
Carbohydrate transport and metabolism
|
I
|
2031
|
Phosphocarrier protein HPr
|
ptsH
|
S
|
-0.3
|
0.9
|
0.4
|
II
|
1095
|
L-fuculose phosphate aldolase
|
sbgE
|
S
|
0.7
| |
2.2*
|
Lipid transport and metabolism
|
Coenzyme transport and metabolism
|
I
|
0657
|
Outer membrane receptor (TonB-dependent transport)
|
btuB
|
S
|
0.2
|
0.6
| |