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Table 3 Essential enzymes and potential chemical inhibitors

From: Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: an initial draft to the two-dimensional annotation

Enzyme name Potential Inhibitor Prior testing? Reference
acetyl-CoA carboxylase pseudopeptide pyrrolidine dione antibiotics SA, B [45]
4-amino-4-deoxychorismate synthase (6s)-6-fluoroshikimate B [46]
Adenosylmethionine decarboxylase CGP 40215A, AdoMao B [47, 48]
asparagine synthase (glutamine-hydrolysing) mucochloric and mucobromic acids, L-cysteine sulfinic acid B [49, 50]
dihydrofolate reductase methylpteridines B [51]
dihydropteroate synthase Sulfone and sulfanilamide sulfa drugs B [52, 53]
3-dehydroquinate synthase carbocyclic inhibitors B [54]
FMN adenylyltransferase (FAD synthase) Riboflavin 5'-pyrophosphate F [55]
glycerol-3-phosphate dehydrogenase (NADP) 5-n-alk(en)ylresorcinols NF [56]
glutamine synthetase L-methionine sulfoximine, aminomethylene-bisphosphonic acid derivatives NF [57, 58]
glutamyl-tRNA reductase see table I in paper NF [59]
GTP cyclohydrolase I Diamino-6-hydroxypyrimidine, pterins NF [60, 61]
Hydroxymethylglutaryl CoA reductase (ir) statins NF [62, 63]
Hydroxymethylglutaryl CoA synthase (ir) beta-lactone, 3-Hydroxy-3-methylglutaryldithio-coenzyme A NF [64, 65]
isopentenyl-diphosphate D-isomerase NE21650 NF [66]
methionine adenosyltransferase adduncts 14 and 16 B [67]
Phosphatidate phosphatase Propranolol NF [68]
phosphoribosylpyrophosphate synthetase MRPP, ARPP NF [69]
riboflavin synthase 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones B [70]
spermidine synthase adenosylspermidine, dicyclohexylamine SA, B [71, 72]
thiamine transport via ABC system azidobenzoyl derivatives of thiamin, methylene blue F [73, 74]
thioredoxin reductase Arsenicals, Aurothioglucose NF [75, 76]
UDP-N-acetylglucosamine 4-epimerase uridine analogs NF [77]
UDP-N-acetylenolpyruvoylglucosamine reductase 4-thiazolidinones B [78]
  1. A reasonable number of enzymes that are computationally predicted to be essential for the growth of S. aureus have inhibitors. These molecules are potential drugs against this organism. The prior testing column uses abbreviations to indicate if we located evidence that the listed compounds had been tested in S. aureus (SA), other bacteria (B), fungi (F), or if no evidence was located (NF). The interested reader should consult the relevant references for full details regarding these potential inhibitors.