Non-classical protein secretion in bacteria

Bendtsen, Jannick D; Kiemer, Lars; Fausbøll, Anders; Brunak, Søren

doi:10.1186/1471-2180-5-58

BMC Microbiology

Table 1 Non-classical secretory proteins in bacteria. The table lists proteins known to be localised extracellularly in Gram-positive bacteria. Many of the proteins are found localised to the cell surface, where as others are found in the surrounding media. Only one study distinguish between cell surface and extracellular localisation of the proteins [21]. ClyA is the only protein from Gram-negative bacteria reported to be non-classically secreted. Proteins listed above the horizontal line have known extracellular functions (see text for details). Abbreviations: Ex – Extracellular, Cs – Cell surface, BS – B. subtilis, MT – M. tuberculosis, LM – L. monocytogenes, EC – E. coli. ^aCytoplasmic abundance of proteins (% of total protein in the cell) in B. subtilis ('-' no data available) [26].

From: Non-classical protein secretion in bacteria

%^a	Protein	Score	Function or similarity	Species	Location	Reference
-	FliD	0.845	Flagellar hook-associated protein 2	BS	Ex	[25]
-	EsxB	0.813	CFP-10	MT	Ex	[13]
-	FlgK	0.795	Flagellar hook-associated protein 1	BS	Ex	[25]
-	XkdK	0.733	PBSX prophage gene	BS	Ex	[25]
-	XlyA	0.684	Amidase (PBSX prophage lysin)	BS	Ex, Cs	[25,54]
-	CwlC	0.634	N-Acetylmuramoyl-L-alanine amidase	BS	Ex, Cs	[25]
-	EsxA	0.557	ESAT-6, 6 kDa early secretory antigenic target	MT	Ex	[17]
-	XepA	0.545	PBSX prophage lytic exoenzyme	BS	Ex	[25]
-	XkdM	0.544	PBSX prophage gene	BS	Ex	[25]
-	GlnA	0.539	Glutamine synthetase 1	MT	Ex	[11,12]
-	ClyA	0.225	Cytotoxic protein	EC	Ex	[23,24]
1.27	Hag	0.218	Flagellin protein	BS	Cs	[9,25]
1.07	SodA	0.209	Superoxide dismutase [Fe] M. tuberculosis	BS, MT, LM	Ex	[6,9,18,28]
-	XkdG	0.090	PBSX prophage gene	BS	Ex	[9]
-	ManA	0.832	Phosphomannose isomerase	LM	Cs	[21]
-	KatA	0.759	Vegetative catalase 1	BS	Ex	[9,25,29]
-	SodA	0.701	Superoxide dismutase	BS	Ex	[9,28]
-	YceD	0.551	Similar to tellurium resistance protein	BS	Ex	[25]
-	DnaK	0.375	Heat shock protein	LM	Cs	[6,21]
-	PdhC	0.152	Pyruvate dehydrogenase (E2 subunit)	LM	Ex, Cs	[6,21]
0.71	PdhA	0.126	Pyruvate dehydrogenase (El α subunit)	BS	Ex	[28]
1.20	CitH	0.118	Malate dehydrogenase	BS	Ex	[25,28]
1.20	Gap	0.118	Glyceraldehyde-3-phosphate dehydrogenase	BS, LM	Ex, Cs	[6,9]
1.23	Eno	0.108	Enolase	BS, LM	Cs	[6,21,25,28]
-	RpoB	0.100	RNA polymerase β subunit	LM	Ex, Cs	[21]
-	RocF	0.082	Arginase	BS	Ex	[25,28]
5.17	EF-Tu	0.075	Elongation factor Tu	LM	Cs	[6,21]
-	RS9	0.073	Ribosomal protein S9	LM	Cs	[21]
-	RocA	0.070	Pyrroline-5 carboxylate dehydrogenase	BS	Ex, Cs	[25]
1.91	Ef-G	0.070	Elongation factor G	BS, LM	Ex, Cs	[6,25,28]
-	RpoC	0.059	RNA polymerase β' subunit	LM	Ex, Cs	[21]
0.76	PdhD	0.052	Pyruvate dehydrogenase (E3 subunit)	BS, LM	Ex	[6,25,28]
-	RL19	0.050	Ribosomal protein L19	LM	Cs	[21]
0.57	PdhB	0.047	Pyruvate dehydrogenase (El β subunit)	BS	Ex	[25,28]
1.30	GroEL	0.035	Class I heat shock protein (chaperonin)	BS	Ex, Cs	[21,28]

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ISSN: 1471-2180

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