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Table 3 Meta-regression analysis to determine sources of heterogeneity

From: In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression

Covariate Coefficient P-value Relative diagnostic odds ratio (RDOR) 95% confidence interval
Intercept 3.248 0.0052 ---- ----
Threshold (S) - 0.072 0.4522 ---- ----
Case control vs. cross-sectional design - 0.292 0.5219 0.75 (0.30 – 1.85)
Blinded vs. unblinded studies 0.441 0.2795 1.55 (0.69 – 3.48)
Chemical vs. other DNA extraction methods - 0.209 0.5877 0.81 (0.38 – 1.74)
IS6110 vs. other target sequences 1.055 0.0074 2.87 (1.34 – 6.16)
Nested vs. regular amplification protocols 1.196 0.0135 3.31 (1.29 – 8.49)
Probe vs. gel-UV detection methods 0.157 0.7222 1.17 (0.49 – 2.81)
Sputum smear positive/both vs negative 0.242 0.8146 1.27 (0.16 – 9.88)
  1. Intercept: constant term in the model
  2. S: indicator of threshold (logit TPR+logit FPR); TPR: true positive rate; FPR: false positive rate RDOR: relative diagnostic odds ratio (obtained by exponentiating the model coefficients)