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Table 4 Designed strategies to enhance 2-acetolactate production, and corresponding predictions for specific growth rates and yields of 2-acetolactate on glucose.

From: Modeling Lactococcus lactis using a genome-scale flux model

  FBA MOMA
  Growth (h-1) Y (C-mol/C-mol) Growth (h-1) Y (C-mol/C-mol)
Reference 0.82 0.31 0.82 0.31
Δldh ΔaldB ΔadhA 0.82 0.32 0.82 0.31
Δldh ΔaldB ΔadhA Δpta 0.56 0.74 0.323 0.34
Δldh ΔaldB ΔadhA Δpta Δfhs 0.56 0.76 0.53 0.75
Δldh ΔaldB ΔadhA Δpta ΔserA 0.56 0.76 0.53 0.74
Δldh ΔaldB ΔadhA Δpta Δzwf 0.38 0.71 0.38 0.75