SCP domain alignment. All sequences shown are prokaryotic except GLIP_HUMAN and VA5_VESVU. The predicted active site residues, based on analysis of the eukaryotic domain , are marked by green or purple arrows. These residues are also almost fully conserved in the prokaryotic sequences except one which falls into an insert region not in the prokaryotic domains, which is marked by the green arrow. The secondary structure of the eukaryotic domain is shown on the line VA5_VESVU_SS.