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Table 1 The inhibition of methionine adenosyltransferase by methionine analogues. The M. smegmatis enzyme was incubated with 1 mM methionine, 10 mM ATP, 20 mM Mg2+, 150 mM K+, and 10 mM inhibitor, as described in the Methods section.

From: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis

Inhibitor Inhibition (%) Inhibitor Inhibition (%)
α-Methyl-DL-methionine 18.8 ± 3.7 3-Methylthio propionaldehyde 18.4 ± 3.7
L-Methionine sulfoxide 4.0 ± 0.8 L-Methionine methyl ester 17.7 ± 3.5
L-Methionine sulfone 9.2 ± 1.8 L-Penicillamine 15.0 ± 3.0
Cycloleucine 25.8 ± 5.1 L-Methionine sulfoximine 12.6 ± 2.5
L-Ethionine 20.4 ± 4.1 (R)-Methioninol 0.0 ± 0.0
L-Methioninamide 23.9 ± 4.8