TY - JOUR AU - Qiu, Ping AU - Cai, Xiao-Yan AU - Wang, Luquan AU - Greene, Jonathan R. AU - Malcolm, Bruce PY - 2002 DA - 2002/09/25 TI - Hepatitis C virus whole genome position weight matrix and robust primer design JO - BMC Microbiology SP - 29 VL - 2 IS - 1 AB - The high degree of sequence heterogeneity found in Hepatitis C virus (HCV) isolates, makes robust nucleic acid-based assays difficult to generate. Polymerase chain reaction based techniques, require efficient and specific sequence recognition. Generation of robust primers capable of recognizing a wide range of isolates is a difficult task. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-2-29 DO - 10.1186/1471-2180-2-29 ID - Qiu2002 ER -