TY - JOUR AU - Nelson, Peter J. AU - Sunamoto, Masaaki AU - Husain, Mohammad AU - Gelman, Irwin H. PY - 2002 DA - 2002/09/19 TI - HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy JO - BMC Microbiology SP - 26 VL - 2 IS - 1 AB - The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium to exit quiescence are largely unknown. Here, we ask whether the expression of HIV-1 genes in infected podocytes induces cyclin D1 and phospho-pRb (Ser780) expression, hallmarks of cyclin D1-mediated G1 → S phase progression. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-2-26 DO - 10.1186/1471-2180-2-26 ID - Nelson2002 ER -