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Table 1 Metabolites with significant differences between mycelia of A. flavus grown in media with or without D-glucal (40 mg/mL)

From: The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus

Compoundsa Relative peak areab Fold increasec P valued
Control D-glucal   
Organic acids     
Furanacetic acid 0.0184 ± 0.0039 2.9291 ± 0.2771 159.10 <0.01
Kojic acid 0.0942 ± 0.0333 0.2076 ± 0.0293 2.20 <0.01
Sugar metabolism     
Ribitol 0.0066 ± 0.0038 0.0168 ± 0.0051 2.56 <0.01
Glycerol 0.0219 ± 0.0055 0.0514 ± 0.0350 2.34 <0.01
D-glucose 0.0133 ± 0.0060 0.1233 ± 0.0400 9.27 <0.01
D-galactose 0.0317 ± 0.0096 0.1750 ± 0.0743 5.53 <0.01
TCA intermediates     
Succinic acid 0.0053 ± 0.0016 0.0020 ± 0.0005 0.37 <0.01
Malic acid 0.0023 ± 0.0013 ND ND ND
Fumaric acid 0.0003 ± 0.0001 0.0002 ± 0.0000 0.53 <0.01
Fatty acids     
Palmitic acid 0.1428 ± 0.0116 0.0856 ± 0.0144 0.60 <0.01
Stearic acid 0.0702 ± 0.0150 0.0468 ± 0.0072 0.66 <0.01
Oleic acid 0.1957 ± 0.0159 0.0377 ± 0.0093 0.19 <0.01
Linoleic acid 0.2647 ± 0.0219 0.1281 ± 0.0212 0.48 <0.01
Others     
Glycine 0.0010 ± 0.0004 0.0004 ± 0.0002 0.39 <0.01
Pyrimidine 0.0018 ± 0.0005 0.0009 ± 0.0001 0.53 <0.01
  1. aIndividual metabolites were identified by GC-TOF MS, as described in the Methods. bRelative peak area as normalized to the peak area of heptadecanoic acid. cFolds represents the relative peak areas in D-glucal-treated samples/peak areas in the control. dStatistical differences between control and D-glucal treated samples were calculated by two-tailed Student’s t-test. N.D.: not detected.