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Table 2 Median lethal dose determination of B. mallei and B. pseudomallei WT and mutant strains

From: Characterization of an autotransporter adhesin protein shared by Burkholderia mallei and Burkholderia pseudomallei

Organism Strain Inoculating dose (CFU) Group size % death LD50(CFU)
B. mallei a ATCC 23344 (WT) 9,100 5 100  
   5,550 5 100  
   910 9 78 346
   455 5 40  
   91 9 11  
B. mallei a bpaC KO (mutant) 10,400 5 100  
   5,200 6 83  
   1,040 9 100 238
   520 5 40  
   104 9 22  
PBS (control)a   0 5 0  
B. pseudomallei b DD503 (WT) 380,000 5 100  
   38,000 5 100 1,202
   3,800 5 100  
   380 5 0  
B. pseudomallei b bpaC KO (mutant) 350,000 5 100  
   35,000 5 100 1,107
   3,500 5 100  
   350 5 0  
PBS (control)b   0 5 0  
  1. amice were monitored daily for clinical signs of illness/morbidity for 10 days post-inoculation.
  2. bmice were monitored daily for clinical signs of illness/morbidity for 6 days post-inoculation.
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