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Table 1 A synthesis of the results showing the basic data in relation to hydrolysis

From: The detection and verification of carbapenemases using ertapenem and Matrix Assisted Laser Desorption Ionization-Time of Flight

  Species Mechanism (n) Hydrolysis, n, time Meropenem MIC (mg/L) Imipenem MIC (mg/L) Ertapenem MIC (mg/L)
Test panel K. pneumoniae KPC-2 (4)   4 - >32 4 - >32 2 - >32
KPC-3 (2) 10/10
KPC (4) 15 min
VIM-1 (3) 3/3 >32 32 - >32 8 - >32
120 min
NDM-1 (4) 4/4 >32 >32 >32
120 min
Classic ESBL (6) 0/6 na na 0.016 - 0.125
120 min
Acquired AmpC 6) 0/6 0.064 - 0.125 0.064 - 0.25 0.032 - 2
120 min
P. aeruginosa VIM-1 (2)   >32 >32 >32
VIM-2 (6) 6/10
VIM (2) 120 min
IMP-14 (1)  
Carba R 0/10 8 - >32 4 - >32 >32
(non-MBL) (10) 120 min
Validation panel A. baumannii OXA 23-like (n = 2) 4/4 >32 >32 >32
OXA 24-like (n = 1) 24 h
OXA 58-like (n = 1)  
P. aeruginosa VIM-1 (3) 2/4 >32 >32 >32
VIM-2 (1) 120 min
K. pneumoniae OXA-48 (3) 3/3 24 h 4 - >32 4 - >32 1 - >32
KPC-2 (4) 4/4 15 min >32 >32 >32
VIM-1 (2) 2/2 120 min >32 >32 >32
NDM-1 (2) 2/2 >32 >32 >32
120 min
E. coli OXA-48 (1) 1/1 24 h 16 8 4
CTX-M-15 (n = 1) 0/2 0.125 - 0.25 0.25 - 0.5 0.064 - 0.125
CTX-M-15+ CIT (n = 1) 120 min and 24 h
  1. *peaks m/z: 476.5, 498.5, 520.5 and 542.5 Da.
  2. A synthesis of the results showing the species, resistance mechanism and MIC range in the test panel and validation panel in relation to the results in the hydrolysis assay based on ertapenem.