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Table 1 A synthesis of the results showing the basic data in relation to hydrolysis

From: The detection and verification of carbapenemases using ertapenem and Matrix Assisted Laser Desorption Ionization-Time of Flight

 

Species

Mechanism (n)

Hydrolysis, n, time

Meropenem MIC (mg/L)

Imipenem MIC (mg/L)

Ertapenem MIC (mg/L)

Test panel

K. pneumoniae

KPC-2 (4)

 

4 - >32

4 - >32

2 - >32

KPC-3 (2)

10/10

KPC (4)

15 min

VIM-1 (3)

3/3

>32

32 - >32

8 - >32

120 min

NDM-1 (4)

4/4

>32

>32

>32

120 min

Classic ESBL (6)

0/6

na

na

0.016 - 0.125

120 min

Acquired AmpC 6)

0/6

0.064 - 0.125

0.064 - 0.25

0.032 - 2

120 min

P. aeruginosa

VIM-1 (2)

 

>32

>32

>32

VIM-2 (6)

6/10

VIM (2)

120 min

IMP-14 (1)

 

Carba R

0/10

8 - >32

4 - >32

>32

(non-MBL) (10)

120 min

Validation panel

A. baumannii

OXA 23-like (n = 2)

4/4

>32

>32

>32

OXA 24-like (n = 1)

24 h

OXA 58-like (n = 1)

 

P. aeruginosa

VIM-1 (3)

2/4

>32

>32

>32

VIM-2 (1)

120 min

K. pneumoniae

OXA-48 (3)

3/3 24 h

4 - >32

4 - >32

1 - >32

KPC-2 (4)

4/4 15 min

>32

>32

>32

VIM-1 (2)

2/2 120 min

>32

>32

>32

NDM-1 (2)

2/2

>32

>32

>32

120 min

E. coli

OXA-48 (1)

1/1 24 h

16

8

4

CTX-M-15 (n = 1)

0/2

0.125 - 0.25

0.25 - 0.5

0.064 - 0.125

CTX-M-15+ CIT (n = 1)

120 min and 24 h

  1. *peaks m/z: 476.5, 498.5, 520.5 and 542.5 Da.
  2. A synthesis of the results showing the species, resistance mechanism and MIC range in the test panel and validation panel in relation to the results in the hydrolysis assay based on ertapenem.