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Table 5 Cefoxitin and Cefepime MIC (by E-test) for selected bacterial isolates

From: Rapid optical determination of β-lactamase and antibiotic activity

S. aureusisolate

Cefoxitin MIC (μg/ml)

Cefoxitin AS*

Cefepime MIC (μg/ml)

Cefepime AS**

#1

3.0 ± 0.0

S

3.3 ± 0.3

S

#2

2.2 ± 0.4

S

1.7 ± 0.3

S

#6

3.0 ± 1.0

S

2.8 ± 0.7

S

#18

4.0 ± 1.0

I

2.0 ± 0.5

S

#19

6.0 ± 1.0

I

3.0 ± 0.6

S

#20

20.0 ± 2.3

R

7.0 ± 0.6

S

  1. *The Cefoxitin Antibiotic Susceptibility (AS) was determined using the CLSI Interpretive Criteria for cefoxitin as an oxacillin surrogate [41].
  2. ≤ 4 μg/ml - Susceptible (S), ≥ 8 μg/ml- Resistant (R), values in between Intermediate (I).
  3. **The Cefepime Antibiotic Susceptibility (AS) was determined using the CLSI Interpretive Criteria for cefepime [41].
  4. ≤ 8 μg/ml - Susceptible (S), 16 μg/ml - Intermediate (I), ≥ 32 μg/ml - Resistant (R)
  5. The results are presented as an average of three independent experiments as Average ± Std. Error. The CLSI recommended quality control for MIC for S. aureus, ATCC 29213 (#1) was included each time, and showed MIC within the expected range for cefoxitin (1–4 μg/ml) and cefepime (1–4 μg/ml) respectively.