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Figure 1 | BMC Microbiology

Figure 1

From: Gene silencing of β-galactosamide α-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells

Figure 1

ST6GAL1-specific siRNAs inhibited ST6Gal 1 expression and SAα2,6Gal synthesis. Respiratory epithelial cells were transfected with control or ST6GAL1 siRNAs (A) At 48 h post-transfection, ST6GAL1 mRNA expression levels were quantified. (B) Candidate siRNAs reduce ST6GAL1 expression in a dose-dependent manner. (C) FACS analysis showed a decrease in SAα2,6Gal expression on ST6GAL1 siRNA-treated cell surfaces. (D) Inhibition of ST6Gal Ι expression due to ST6GAL1 siRNAs. (E) We used ST6GAL1 siRNAs at various concentrations and they were not cytotoxic, except at 50 nM. a P < 0.05.

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BMC Microbiology

ISSN: 1471-2180

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