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Table 6 C. jejuni proteins responding to decreased iron concentration assessed by comparing protein expression after growth on MH + blood and on MH medium

From: The CJIE1 prophage of Campylobacter jejuni affects protein expression in growth media with and without bile salts

Protein Locus in NCTC11168 GI number Log2change in MH medium
    00-2425 00-2426
Iron acquisition     
Iron-uptake ABC transporter ATP-binding protein CfbpC, putative Cj0173c gi|218561852 1.27 ± 0.75 1.10 ± 0.53
Iron ABC transporter, permease CfbpB, putative Cj0174c gi|121612175 0.80 ± 0.71 0.90 ± 0
Iron-uptake ABC transporter, periplasmic iron-binding protein CfbpA, putative Cj0175c gi|218561854 2.00 ± 1.30 1.97 ± 1.27
Iron transport protein, putative Cj0177 gi|218561856 3.30 ± 0.17 2.73 ± 1.05
TonB-denpendent outer membrane receptor, putative Cj0178 gi|218561857 2.70 ± 0.56 2.97 ± 0.29
Biopolymer transport ExbB protein, TonB transport system Cj0179 gi|218561858 3.03 ± 0.32 3.37 ± 1.61
Periplasmic TonB transport protein Cj0753c gi|315124276 3.5 (single value) 3.5 (single value)
Ferric receptor CfrA Cj0755 gi|57237601 2.37 ± 0.15 2.23 ± 0.81
Enterochelin uptake ATP-binding protein CeuD Cj1354 gi|218562963 2.00 ± 1.06 2.00 ± 0.56
Enterochelin ABC transporter, periplasmic enterochelin-binding protein CeuE Cj1355 gi|121612138 1.80 ± 0.66 1.40 ± 0.26
Periplasmic protein P19 Cj1659 gi|157415879 1.97 ± 1.50 2.10 ± 1.04
Iron permease, putative Cj1658 gi|218563246 1.97 ± 1.04 1.70 ± 1.01
Heme iron utilization protein, putative Cj1613c gi|121612296 3.60 ± 0.95 3.70 ± 0.5
TonB-dependent heme receptor ChuA Cj1614 gi|57238627 3.35 ± 0.35 4.20 ± 0
TonB-dependent heme receptor ChuA Cj1614 gi|157415833 1.80 ± 0.70 1.73 ± 0.87
TonB-dependent heme receptor ChuA Cj1614 gi|121613006 1.20 ± 0.56 0.33 ± 0.64
Hemin ABC transporter, permease protein, putative ChuB Cj1615 gi|153951720 3.17 ± 0.55 2.93 ± 1.19
Hemin uptake system ATP-binding protein ChuC , putative Cj1616 gi|218563205 2.97 ± 0.74 3.07 ± 0.50
Hemin uptake system periplasmic hemin-binding protein, putative Cj1617 gi|218563206 2.83 ± 0.59 2.53 ± 0.42
Biopolymer transport ExbD protein, TonB transport system Cj1629 gi|153952038 1.63 ± 0.81 1.57 ± 0.49
Integral membrane protein, putative Cj1660 gi|218563248 1.27 ± 0.81 1.5 ± 0.79
ABC transporter permease, putative Cj1661 gi|218563249 1.67 ± 0.97 1.57 ± 0.67
Integral membrane protein, putative Cj1662 gi|218563250 1.93 ± 1.15 1.60 ± 0.87
ABC transporter ATP-binding protein Cj1663 gi|157415883 1.53 ± 0.80 1.53 ± 0.51
Oxidative stress     
Thioredoxin reductase Cj0146c gi|218561827 0.93 ± 0.47 0.87 ± 0.5
Antioxidant, AhpC/Tsa family Cj0334 gi|157414631 0.97 ± 0.32 0.70 ± 0.20
Catalase Cj1385 gi|121612952 3.37 ± 0.23 2.80 ± 0.56
Thioredoxin-like protein Cj1664 gi|121613144 1.23 ± 0.91 1.27 ± 1.08
Anthranilate synthesis     
Anthranilate synthase component I Cj0345 gi|121612335 0.80 ± 0.75 0.87 ± 0.71
Anthranilate synthase component II Cj0346 gi|121612640 0.67 ± 0.60 0.60 ± 0.46
N-(5′phosphoribosyl)anthranilate isomerase Cj0347 gi|157414644 1.00 ± 0.53 0.83 ± 0.65
Chemotaxis     
Methyl-accepting chemotaxis protein Cj1189c gi|121613242 0.70 ± 1.10 0.07 ± 0.06
Methyl-accepting chemotaxis protein Cj1506c gi|121613017 2.0 ± 1.31 3.23 ± 2.40
Methionine biosynthesis     
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE Cj1201 gi|157415465 0.50 ± 0.35 1.20 ± 0.26
Homoserine O-succinyltransferase MetA Cj1726c gi|121613233 0.80 ± 0.35 1.53 ± 0.55
Homoserine O-acetyltransferase MetB Cj1727c gi|315125108 1.27 ± 0.57 1.93 ± 0.9
Molybdate transport     
Molybdate transport system ATP-binding protein Cj0300c gi|157414597 0.67 ± 0.15 0.77 ± 0.25
Hypothetical protein C8J_0279 molybdenum-pterin-binding protein Cj0302 gi|157414599 0.30 (single value) 0.67 ± 0.21
Molybdate transport system substrate-binding protein Cj0303 gi|157414600 0.83 ± 0.75 0.77 ± 0.25
Hypothetical proteins     
Hypothetical protein C8J_0062 Cj0069 gi|157414383 −0.63 ± 0.06 −0.60 ± 0.17
Hypothetical protein CJJ81176_0110 Cj0073c gi|121613178 −0.93 ± 0.68 −0.57 ± 0.35
Hypothetical protein C8J_0189 Cj0200c gi|157414509 0.67 ± 0.81 0.80 ± 0.78
Hypothetical protein Cj0427 Cj0427 gi|218562085 −1.47 ± 0.67 0.07 ± 0.58
Hypothetical protein CJJ81176_0676 Cj0648 gi|121613289 0.70 ± 0.28 0.50 ± 0.36
Hypothetical protein C8J_1185 Cj1242 gi|157415505 −0.60 (single value) −1.10 ± 0.71
Hypothetical protein C8J_1529 Cj1627c gi|157415847 0.60 ± 0.20 0.50 ± 0.61
Hypothetical protein CJJ81176_1628 Cj1637c gi|121613390 −0.33 ± 0.15 −0.73 ± 0.35
Hypothetical protein C8J_1561 Cj1659 gi|157415879 1.97 ± 1.50 2.10 ± 1.04
Hypothetical protein CJE0598 CJIE2 prophage not present gi|57238304 1.10 ± 0.28 0.77 ± 0.40
Hypothetical protein CXIVA_22050 not present gi|339443269 0.67 ± 0.57 0.50 ± 0.53
Transporters     
Sodium/dicarboxylate symporter Cj0025c gi|121612756 0.80 ± 0.66 0.40 ± 0.44
Anaerobic C4-dicarboxylate transporter Cj0088 gi|218561769 −1.10 ± 0.61 −0.63 ± 0.23
OPT family oligopeptide transporter Cj0204 gi|121613125 0.73 ± 0.21 0.50 ± 0.17
Other function or unknown function     
Non-haem iron protein Cj0012c gi|218561705 −0.83 ± 0.61 −0.77 ± 0.64
Cytochrome c family protein Cj0037c gi|121612292 0.93 ± 0.21 1.03 ± 0.35
Aspartate ammonia-lyase Cj0087 gi|157414400 −1.10 ± 0.50 −1.1 ± 0.40
Periplasmic protein, putative Cj0093 gi|218561774 0.80 ± 0.53 0.80 ± 0.56
Superoxide dismutase, Fe Cj0169 gi|157414485 −1.23 ± 0.84 −1.20 ± 1.47
Superoxide dismutase, Fe Cj0169 gi|153951398 −3.70 ± 2.95 −0.93 ± 0.97
Integral membrane protein Cj0236c gi|153952171 0.53 ± 0.75 0.97 ± 0.76
Chemotaxis histidine kinase Cj0284c gi|218561946 −0.83 ± 0.61 −0.53 ± 0.42
Ferredoxin 4Fe-4S Cj0333c gi|121612302 −1.10 ± 0.89 0.53 ± 0.15
Tryptophan synthase subunit alpha Cj0349 gi|121613100 0.67 ± 0.47 0.80 ± 0.56
Cytochrome c551 peroxidase Cj0358 gi|121612870 −0.67 ± 0.55 0.50 ± 0.17
Putative integral membrane protein Cj0421c gi|218562079 1.00 ± 0.71 0.73 ± 0.12
Putative periplasmic protein Cj0425 gi|218562083 1.70 (single value) 1.10 (single value)
Succinate dehydrogenase flavoprotein subunit Cj0437 gi|218562095 −0.70 ± 0.44 −0.6 ± 0.87
DNA polymerase III subunit epsilon Cj0452 gi|218562107 −0.23 ± 0.21 −0.67 ± 0.31
Thiamine biosynthesis protein ThiC Cj0453 gi|121613325 −2.23 ± 0.38 −1.83 ± 0.32
ATP-dependent chaperone protein ClpB Cj0509c gi|121613623 −0.33 ± 0.15 −0.67 ± 0.15
2-oxoglutarate-acceptor oxidoreductase subunit OorD Cj0535 gi|157414816 −0.87 ± 0.55 0.63 ± 0.66
2-oxoglutarate-acceptor oxidoreductase subunit OorA Cj0536 gi|157414817 −0.73 ± 0.32 −0.67 ± 0.15
Aminohydrolase family protein, putative Cj0556 gi|218562208 0.90 ± 0.57 1.13 ± 0.71
Quinol dehydrogenase membrane component NapH Cj0782 gi|121612888 −0.67 ± 0.49 −0.55 ± 0.35
Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase Cj0835c gi|218562463 −1.00 ± 0.26 −0.93 ± 0.59
Thermonuclease family protein Cj0979c gi|121612563 −0.83 ± 0.38 −0.73 ± 0.68
Amino acid transporter, periplasmic solute-binding protein, putative Cj0982c gi|218562598 1.03 ± 0.38 0.77 ± 0.4
Arginyl-tRNA-protein transferase Cj1035c gi|121613462 −0.73 ± 0.29 −0.60 ± 0.26
Flippase Cj1130c gi|218562744 −0.27 ± 0.38 −0.67 ± 0.42
Cytochrome c553 Cj1153 gi|157415419 −0.77 ± 0.25 −0.53 ± 0.38
Cyclopropane fatty acid biosynthesis Cj1183c gi|57238055 1.07 ± 0.67 0.73 ± 0.32
NLPA family lipoprotein, putative Cj1200 gi|218562812 0.47 ± 0.83 1.20 ± 0.56
Hemerythrin family non-heme iron protein Cj1224 gi|121612625 −0.73 ± 0.25 −0.07 ± 0.21
Quinone-reactive Ni/Fe-hydrogenase, small subunit Cj1267c gi|157415531 −0.63 ± 0.46 −0.57 ± 0.21
Endoribonuclease L-PSP, putative Cj1388 gi|218562997 0.77 ± 0.21 0.40 ± 0.36
Putative Ni/Fe-hydrogenase small subunit Cj1399c gi|218563003 0.73 ± 0.31 0.57 ± 0.15
Hypothetical protein C8J_1356 ATP/GTP-binding protein Cj1450 gi|157415675 −0.87 ± 0.38 −0.80 ± 0.46
Transformation system protein CtsX Cj1472 gi|121612126 −0.55 ± 0.7 −1.20 (single value)
Transformation system protein CtsP Cj1473c gi|121613067 −0.65 ± 0.07 −0.13 ± 0.31
Pyruvate-flavodoxin oxidoreductase Cj1476c gi|315124909 −0.87 ± 0.38 0.63 ± 0.42
Formate dehydrogenase, iron-sulfur subunit Cj1510c gi|157415732 −0.73 ± 0.71 −0.73 ± 0.45
Dephospho-CoA kinase Cj1530 gi|218563123 0.73 ± 0.68 0.57 ± 0.74
Multidrug transporter membrane component/ATP-binding component Cj1587c gi|121613099 1.40 ± 0.53 1.00 ± 0.44
Two-component regulator (DNA binding response regulator), putative Cj1608 gi|218563197 −0.07 ± 0.31 −2.50 ± 1.65
Citrate synthase Cj1682c gi|157415898 −0.80 ± 0.36 −0.73 ± 0.21
50S ribosomal protein L2 Cj1704c gi|121612340 −0.47 ± 0.85 −0.80 ± 0.46
2-isopropylmalate synthase Cj1719c gi|121612265 0.83 ± 0.68 0.67 ± 0.21
Hypothetical protein CJE0598 CJIE2 prophage CJE0598 gi|57238304 1.10 ± 0.28 0.77 ± 0.4
Flagellin CJE1526 gi|57238729 −0.87 ± 0.25 −0.80 ± 0.44