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Table 3 Distribution of virulence genes and resistance determinants among lineages, CCs and STs of E. faecium

From: Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin

Lineage/CC/ST

MT

Isolation site

Virulence genes

Resistance determinants

Transposon genes

Plasmidrepgenes

Plasmid TAS

   

esp/intA

fms5

fms17

fms19

fms21

pbp5

GyrA

ParC

aac(6′)-Ie-aph(2″)

ant(6′)-Ia

tet(M)

tet(L)

tet(S)

intTn916

tndX

rep1 pIP501

rep2 pRE25

rep17 pRUM

rep18 pEF418

rep pLG1

rep pMG1

axe-txe

ω-ε-ζ

relBE

Lineage 17

17 (2)

1, 8

W-EFF

2

2

2

2

2

pbp5-30

S84R

R61G S80R

  

1

1

   

2

2

1

2

2

 

1

1

 

386

7

W-MOut

1

1

1

1

1

    

1

     

1

1

1

1

1

 

1

1

 

Lineage 18

18 (3)

1 (3)

D-EFF, W-MOut

 

3

3

3

1

pbp5-20

S84Y

R61G S80I

1

2

3

3

   

1

2

1

 

3

    

262

10

W-EFF

 

1

1

 

1

pbp5-25

S84Y

R61G

1

 

1

1

   

1

1

  

1

  

1

 

574

402

VR

 

1

  

1

        

1

     

1

    

Lineage 78

78 (4)

159 (4)

W-EFF, W-MOut

4

4

4

4

4

pbp5-28

S84R/Y

R61G S80R

2

1

2

2

   

1

4

4

2

4

 

4

3

 

266 (2)

139 (2)

W-INF, D-EFF

 

2

1

2

2

pbp5-24

   

1

1

  

2

 

1

1

2

 

2

 

2

  

323

12

D-MOut

 

1

1

1

1

pbp5-26

wt

R61G S80I

1

1

1

1

  

1

1

1

  

1

    

564

302

D-EFF

1

1

1

 

1

pbp5-29

S84I

R61G S80R

 

1

     

1

1

1

 

1

 

1

1

 

653

302

W-EFF

    

1

nd

S84I

R61G S80R

 

1

      

1

1

      

CC5

29 (2)

 

W-EFF, W-MOut

 

2

1

 

1

          

2

   

1

    

66

 

W-MOut

 

1

1

 

1

     

1

1

       

1

 

1

  

97

 

W-EFF

    

1

 

wt

R61G S80R

       

1

   

1

    

123

 

W-EFF

 

1

 

1

  

wt

R61G

       

1

  

1

1

    

148

 

W-MOut

 

1

   

pbp5-30

wt

R61G S80R

 

1

1

1

  

1

    

1

    

168

 

W-MOut

 

1

1

  

pbp5-31

   

1

1

1

 

1

 

1

1

1

 

1

 

1

  

505

 

W-EFF

 

1

    

wt

R61G

       

1

   

1

    

588

 

D-MOut

 

1

   

pbp5-30

   

1

1

1

  

1

 

1

  

1

    

635

 

D-EFF

  

1

 

1

          

1

   

1

    

636

 

W-EFF

 

1

    

wt

R61G

       

1

        

637

 

W-EFF

 

1

1

 

1

 

wt

R61G

       

1

   

1

    

638

 

W-EFF

  

1

   

wt

R61G S80I

       

1

        

642

 

W-EFF

 

1

1

1

           

1

   

1

    

645

 

D-EFF

 

1

1

            

1

   

1

   

1

646

 

W-EFF

 

1

1

       

1

  

1

 

1

        

649

 

W-BR

 

1

1

1

 

pbp5-32

wt

R61G

 

1

              

650 (3)

 

D-EFF

 

3

3

  

pbp5-27

   

2

2

2

 

1

 

1

3

       

CC 9

8

 

D-EFF

 

1

1

1

1

    

1

1

     

1

1

1

1

 

1

  

640

 

W-EFF

 

1

1

1

1

              

1

    

CC 22

21

 

W-EFF

  

1

1

1

    

1

1

1

 

1

     

1

    

22

 

W-EFF

 

1

1

 

1

        

1

1

    

1

    

25

 

W-EFF

  

1

 

1

pbp5-32

wt

R61G

1

       

1

  

1

    

32 (3)

 

W-EFF

 

3

3

1

  

wt

R61G

       

2

   

1

    

92

 

W-EFF

 

1

1

 

1

          

1

   

1

    

441

 

W-EFF

 

1

1

 

1

     

1

1

    

1

  

1

  

1

 

533

 

W-EFF

 

1

                 

1

1

   

633

 

W-EFF

 

1

        

1

 

1

1

 

1

        

644

 

D-EFF

 

1

1

 

1

          

1

   

1

    

CC27

652

 

W-EFF

  

1

 

1

          

1

   

1

    

CC46

47

 

VR

 

1

  

1

          

1

   

1

    

69

 

D-EFF

 

1

1

 

1

          

1

1

  

1

    

CC94

94

 

W-MOut

  

1

 

1

          

1

   

1

    

361 (4)

 

D-EFF, D-MOut

 

3

4

4

4

pbp5-29

   

1

 

1

     

1

 

4

   

1

CC296

296

 

W-EFF

 

1

 

1

                    

CC639

639

 

W-EFF

 

1

1

 

1

          

1

   

1

    

CC648

634

 

W-EFF

 

1

  

1

          

1

   

1

   

1

648

 

W-EFF

 

1

1

 

1

          

1

   

1

    

Doubletons

632

 

W-MOut

 

1

  

1

              

1

    

Singletons

264

 

W-INF

 

1

 

1

1

          

1

1

  

1

  

1

 

641

 

D-EFF

 

1

1

 

1

              

1

    

643

 

W-EFF

 

1

  

1

          

1

1

  

1

  

1

 

647

 

W-MOut

   

1

1

          

1

   

1

1

   

651

 

D-EFF

  

1

1

1

           

1

  

1

   

1

654

 

VR

   

1

1

          

1

1

  

1

   

1

All (69)

  

8

57

49

29

46

   

6

17

20

17

1

9

4

39

27

14

7

55

2

12

10

5

  1. CC, clonal complex; ST, sequence type; MT, MLVA-type; nd, not determined due to lack of amplification of the pbp5 gene; wt, wild-type; STs associated with MDR phenotype in bold.
  2. Abbreviations of sampling points’ locations and their description provided in Figure 1.
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BMC Microbiology

ISSN: 1471-2180

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