Scheme of the rearrangements identified in the IgG-binding domains of spa -gene in samples from Oxfordshire. Notes: The insertions are indicated by grey rectangles. The deletions indicated by dotted thin lines. Black arrows indicate annealing sites for spaT3-F novel primer; grey arrows indicates annealing site for 1095 F standard primer; white arrow indicates annealing site for 1517R standard primer. Grey rectangles with arrows indicate insertions with additional binding sites for primers. Panel (a) indicates deletions found only in community samples, panel (b) indicates deletions found only in inpatient samples and panel (c) indicates deletions found both in community and inpatient samples. Spa gene: s – signal sequence, E, D, A, B, C sequences encoding IgG-binding domains, X - region which lacks IgG-binding activity and consists of repetitive region (Xr) and C-terminal region (Xc). Asterisk indicates deletion previously described by Baum et al., 2009. Dagger indicates deletions/insertions leading to strains being designated non-typeable using the standard primers.