Skip to main content

Table 2 Synergistic activity of DSF signal (50 μM) with antibiotics against various bacterial species

From: Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens

 

MIC (μg/ml)

Bacteria

Gm*

Km

Rm

Am

Tc

Cm

Tm

B. thuringiensis

MEOH

4

32

1

1

4

4

512

DSF

0.25

2

0.25

0.25

2

2

128

S. aureus

MEOH

0.125

2

0.0625

2

4

4

NA#

DSF

0.016

1

0.0625

1

4

4

NA

M. smegmatis

MEOH

0.16

0.32

NA

256

0.16

6.4

0.64

DSF

0.08

0.08

NA

256

0.16

3.2

0.32

N. subflava

MEOH

2

8

0.5

2

2

0.5

128

DSF

1

4

0.5

2

2

0.5

128

P. aeruginosa

MEOH

1.28

128

NA

128

32

128

64

 

DSF

0.64

64

NA

128

32

128

64

  1. *Abbreviations: Gm gentamicin, Km kanamycin, Rm rifampicin, Am ampicillin, Tc tetracycline, Cm chloramphenicol, and Tm trimethoprim.
  2. # NA means the bacterial species was not sensitive to the tested antibiotic.
Back to article page

BMC Microbiology

ISSN: 1471-2180

Contact us