Skip to main content

Table 2 Synergistic activity of DSF signal (50 μM) with antibiotics against various bacterial species

From: Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens

  MIC (μg/ml)
Bacteria Gm* Km Rm Am Tc Cm Tm
B. thuringiensis MEOH 4 32 1 1 4 4 512
DSF 0.25 2 0.25 0.25 2 2 128
S. aureus MEOH 0.125 2 0.0625 2 4 4 NA#
DSF 0.016 1 0.0625 1 4 4 NA
M. smegmatis MEOH 0.16 0.32 NA 256 0.16 6.4 0.64
DSF 0.08 0.08 NA 256 0.16 3.2 0.32
N. subflava MEOH 2 8 0.5 2 2 0.5 128
DSF 1 4 0.5 2 2 0.5 128
P. aeruginosa MEOH 1.28 128 NA 128 32 128 64
  DSF 0.64 64 NA 128 32 128 64
  1. *Abbreviations: Gm gentamicin, Km kanamycin, Rm rifampicin, Am ampicillin, Tc tetracycline, Cm chloramphenicol, and Tm trimethoprim.
  2. # NA means the bacterial species was not sensitive to the tested antibiotic.