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Table 3 Genes differentially expressed in H. influenzae R3264 at pH 8.0 compared to pH 6.8

From: There is a specific response to pH by isolates of Haemophilus influenzae and this has a direct influence on biofilm formation

Genes up-regulated at pH 8.0 compared to 6.8

Iron uptake genes

Gene

Log2fold

p -value

FDR

Comment

hitA

1.76

9.65×10-12

2.46×10-9

Iron uptake ABC, periplasmic domain

hitB

1.31

8.77×10-7

1.11×10-4

Iron uptake ABC, permease domain

tbp2

1.54

2.92×10-5

2.74×10-3

Iron-binding OM receptor

tbp1

1.49

3.53×10-7

5.26×10-5

Transferrin binding protein

h×uB

1.02

8.62×10-5

7.32×10-3

Heme-hemopexin utilization protein

Metabolic genes

Gene

Log 2 fold

p -value

FDR

Comment

glpB

1.08

5.35×10-5

4.77×10-3

Glycerol metabolism

Genes of unknown function

Gene

Log 2 fold

p -value

FDR

Comment

HI0997

1.34

8.95×10-4

5.51×10-2

Hypothetical protein

HI1427

1.31

4.17×10-7

5.72×10-5

Transmembrane protein

Genes down-regulated at pH 8.0 compared to 6.8

Gene

Log 2 fold

p -value

FDR

Comment

HI1349

-1.23

5.14×10-6

5.10×10-4

Ferritin

ahpD

-1.72

1.24×10-7

2.01×10-5

Stress response